Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Persistence of SARS-CoV-2 IgG and Its Avidity Compared with Neutralizing Antibodies among Health Care Workers in a Tertiary Care Hospital, South India – a One Year Follow Up Study

Anagoni Srikar
,
Mudhigeti Nagaraja
ORCID logo ,
Alladi Mohan
,
Pottekula Prakash
,
Kodavala Sireesha
,
Nallapireddy Umapathi
,
Anju Verma
,
Usha Kalawat
* ORCID logo
Version 1 : Received: 16 September 2023 / Approved: 18 September 2023 / Online: 19 September 2023 (03:35:40 CEST)

How to cite: Srikar, A.; Nagaraja, M.; Mohan, A.; Prakash, P.; Sireesha, K.; Umapathi, N.; Verma, A.; Kalawat, U. Persistence of SARS-CoV-2 IgG and Its Avidity Compared with Neutralizing Antibodies among Health Care Workers in a Tertiary Care Hospital, South India – a One Year Follow Up Study. Preprints 2023, 2023091211. https://doi.org/10.20944/preprints202309.1211.v1 Srikar, A.; Nagaraja, M.; Mohan, A.; Prakash, P.; Sireesha, K.; Umapathi, N.; Verma, A.; Kalawat, U. Persistence of SARS-CoV-2 IgG and Its Avidity Compared with Neutralizing Antibodies among Health Care Workers in a Tertiary Care Hospital, South India – a One Year Follow Up Study. Preprints 2023, 2023091211. https://doi.org/10.20944/preprints202309.1211.v1

Abstract

: (1) Background: Healthcare workers (HCWs) are a well-known risk group for coronavirus infections with increased working hours in a potentially infectious environment. We evaluated both IgG and Neutralizing antibody levels, with IgG avidity index and persistence among health workers. (2) Methods: 1001 HCWs were tested for both IgG and Neutralizing antibodies. IgG avidity testing and one-year follow-up testing were done on selected HCWSs. (3) Results: COVID-19 IgG antibody levels were high among 299 (94.62%) HCWs with a history of COVID-19 infection (p <0.0001) compared with 479 (69.92%) HCWs who were not infected with COVID-19 during the first and second wave. A total of 899 (89.81%) HCWs had more than 50% neutralizing antibodies while the remaining 102 (10.19%) HCWs had less than 50% of Neutralizing antibodies. The avidity index was maintained at almost 40% (Gray zone). Both antibody levels were found markedly increased after one year when compared to initial results. (4) Conclusions: Healthcare workers are at a 2.29-fold higher risk of infection; Two folds higher IgG levels in HCWs involved in COVID-19 duty and their persistence for a longer time than in other groups signifies IgG antibody role in the prevention of severe disease in HCWs involved in Covid-19 patient care.

Keywords

SARS-COV-2; Health care workers; IgG antibody; Neutralizing antibody; Antibody avidity

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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