Version 1
: Received: 17 September 2023 / Approved: 18 September 2023 / Online: 19 September 2023 (03:49:18 CEST)
How to cite:
Hur, K.Y. Reappraisal of Duodenal Exclusions and Biliopancreatic Limb Length in Metabolic Surgery for Nonobese Patients with Type 2 Diabetes. Preprints2023, 2023091188. https://doi.org/10.20944/preprints202309.1188.v1
Hur, K.Y. Reappraisal of Duodenal Exclusions and Biliopancreatic Limb Length in Metabolic Surgery for Nonobese Patients with Type 2 Diabetes. Preprints 2023, 2023091188. https://doi.org/10.20944/preprints202309.1188.v1
Hur, K.Y. Reappraisal of Duodenal Exclusions and Biliopancreatic Limb Length in Metabolic Surgery for Nonobese Patients with Type 2 Diabetes. Preprints2023, 2023091188. https://doi.org/10.20944/preprints202309.1188.v1
APA Style
Hur, K.Y. (2023). Reappraisal of Duodenal Exclusions and Biliopancreatic Limb Length in Metabolic Surgery for Nonobese Patients with Type 2 Diabetes. Preprints. https://doi.org/10.20944/preprints202309.1188.v1
Chicago/Turabian Style
Hur, K.Y. 2023 "Reappraisal of Duodenal Exclusions and Biliopancreatic Limb Length in Metabolic Surgery for Nonobese Patients with Type 2 Diabetes" Preprints. https://doi.org/10.20944/preprints202309.1188.v1
Abstract
Metabolic surgery can promote comprehensive physiological improvements to alleviate metabolic disorders, particularly for patients with type 2 diabetes. Nevertheless, the therapeutic scope has been limited owing to unexpectedly inconsistent surgical outcomes. Therefore, this study to overcome these obstacles by determining the fundamental mechanism underlying the conflicting outcomes. The surgical anatomy, clinical course, and outcomes of various metabolic surgeries, including modified duodenal-jejunal bypass (DJB) procedures, were compared to understand the specific surgical patterns from different perspectives comprehensively. Patients in the nonobese group were exclusively included to prevent confounding effects from overweight patients with type 2 diabetes. Following intestinal anastomosis, the epithelial identity of the succeeding intestine was replaced by that of the proximal epithelium owing to altered crosstalk between the epithelium and opposing mesenchymal cells. Subsequent intestinal compensatory proliferation and rapid turnover rate accelerate the spread of the replaced epithelium. The main factors contributing to inconsistent outcomes of metabolic surgery are inadequate duodenal exclusion and inappropriate biliopancreatic limb length. Replacement of enteroendocrine cells during regeneration can lead to inconsistent outcomes in metabolic surgery. The type and density of enteroendocrine cells distributed at the terminal end of the proximal intestine play a significant role in diverse outcomes of metabolic surgery.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
