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Preprints on COVID-19 and SARS-CoV-2
Submitted:
17 September 2023
Posted:
18 September 2023
You are already at the latest version
Control group, n=52 | Ozone group, n=57 |
---|---|
3x vaccinated: n=33 (63,5%); 2x vaccinated: n=19 (36,5%) |
3x vaccinated: n=31 (54,4%); 2x vaccinated: n=26 (45,6%) |
female n=33, male n=19 age 20 to 55 |
female n=24, male n=33 age 20 to 55 |
MAH: 1x per week, 8 treatments RI: 2x per week during 2 weeks, then 1x per week; 15-16 treatments |
Type of study | Results | Application route | References |
---|---|---|---|
Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and proinflammatory cytokines in multiple sclerosis patients | Secondary prevention GSH increase. |
Rectal insufflation 20mg/L | Livan Delgado-Roche, Mario Riera-Romo, Fernando Mesta, Yanet Hernández-Matos, Juan M. Barrios, Gregorio Martínez-Sánchez, Said M. Al-Dalaien. European Journal of Pharmacology, 2017, 811, 148-154 |
Ozone influence on the RBC metabolism” (german Einfluss auf den Erythrozyten-Stoffwechsel). Clinical trial . | Metabolic activation in RBC´s: 2,3-DPG and ATP increase. See text. | Rectal insufflation | Viebahn-Hänsler, R. Washüttl. J. Wasser, G. Gutzen, U.1995 [15] |
Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in older patients (60-70 years) with oxidative etiology diseases. Controlled clinical study. | Positive influence on aging process. See text. | Rectal insufflation | León Fernández, O. S., Takon Oru, G., Viebahn-Hänsler, R., López Cabreja, G., Serrano Espinosa, I., García Fernández, E. 2022 [19] |
Medical ozone increases methotrexate clinical response and improves cellular redox balance in patients with rheumatoid arthritis. Clinical trial. |
Statistical significant reduction of liver toxicity in patients with rheumatoid arthritis during MTX treatment. See text. | 10 rectal insufflations in 10 days | León, O.S., Viebahn-Haensler, R., López, C.G., Serrano, E.I., Hernández, M.Y., Delgado, R.L., Tamargo, S.B., Takon, O.G., Polo, V.J.C., 2016. [27] |
Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects. |
Prevention from toxicity, mainly in animal models | systemic applications | Bernardino Clavo, Francisco Rodríguez-Esparragó , Delvys Rodríguez-Abreu,Gregorio Martínez-Sánchez, Pedro Llontop, David Aguiar-Bujanda,Leandro Fernández-Pérez and Norberto Santana-Rodríguez Antioxidants 2019, 8, 588; doi:10.3390/antiox8120588 |
Type of study | Results | Application route | References |
---|---|---|---|
Ozone Therapy for Prevention and Treatment of COVID-19. Review. | 4 publications in prevention. | Different forms of application. | Gregorio Martínez-Sánchez1Journal of Exploratory Research in Pharmacology, April 2022. DOI: 10.14218/JERP.2022.00015 |
Intravenous ozonized saline therapy as prophylaxis for healthcare workers (HCWs) in a dedicated COVID-19 hospital in India. A retrospective study | Less infections in the ozone group (4.6%) than in the control (14.03%). N=64 (235). | Ozonized saline. | A. Sharma, M. Shah, H. Sane, N. Gokulchandran, A. Paranjape, P. Khubchandani, J. Captain, S. Shirke, P. Kulkarni. European Review for Medical and Pharmacological Sciences, 2021; 25, 3632-3639 |
Immunity Prophylaxis With Ozone Therapy Review Report. | 2.19 % incidence rate (n=320). | Minor autohemotherapy. | Dr. Mili Shah, Jignasha Captain and Gayatri Ganu. ejbps, 2020, 7, 86-88. |
Could the minor autohemotherapy be a complementary therapy for healthcare professionals to prevent COVID-19 infection? | (n=73) No infection or positive test. |
Minor autohemotherapy. | Aydan Orscelik, Burak Karaaslan, Betul Agiragac, Ilker Solmaz, Murat Parpucu. Ann Med Res 2021, 28, 1863-9 DOI:10.5455/annalsmedres.2020.11.1133 |
Could ozone therapy be used to prevent COVID-19? Clinical Trial. | 2 of 71 persons were tested positive.Retrospective, no control. 45 % medical professionals. See text. | Major autohemotherapy 10 treatments. | Kardelen Gencer-Atalay1 , Tulay Sahin-Marmara Med J 2022;35(2): 196-201. http://doi.org/10.5472/marumj.1121363. [22] |
COVID-19 profilaxis with ozone therapy | n=9, good effect but no protection from further infection. | Rectal insufflation. | Falzoni, W.; Senvaitis, M. I.; Iwasa, S. Acupuncture and Electro-TherapeuticsResearch,2021,46,3 5-36,. |
Comparative analysis of 2 groups of people according to age and sex, vaccinated triple versus covid-19, were subjected to quantitative analysis of antibodies and B lymphocytes after ozone therapy. Clinical trial. | See text. | Major autohemotherapy . |
Medina, José German, Journal of Ozone Therapy, 2022. 6, 11-12. [23] |
The Role of Ozone Therapy as Adjuvant in the Management of Covid-19 in Indonesia. Clinical trial. | See text. | Major autohemotherapy, Rectal insufflation, vaginal insufflation. | Dian Chaijadi, Asep Hendradiana, Peter Djoko Tjahjono, Endang Kusumaningsih, Hariyanto, Carles Siagian, Djaja Surya Atmadja, Renate Viebahn-Hänsler. Indonesian Police Central Hospital and Faculty of Medicine, Indonesia University, Jakarta, proceedings Association IOA in Milan 2023. [21] |
Injury biomarkers: Oxidative stress markers | Protective markers: antioxidants | Clinical parameters |
---|---|---|
TH (total hydroperoxides) | total SOD (superoxide dismutase) CAT (catalase) |
DAS (disease activity score) PAIN |
MDA (malondialdehyde) AOOP (advanced oxidation protein products) |
GSH (reduced glutathione) | HAQ: DI, (health Assessment disability questionnaire) |
NO (nitrogen monoxide) | GGT (gamma glutamyl transferase) | Auto antibodies CCP (anti-cyclic citrullinated peptides) |
Application | Ozone conc. | Ozone volume | Treatment frequency |
---|---|---|---|
Rectal ozone-insufflation | 15 - 25 µg/ml In general: 10 to max. 40 µg/ml |
150–300 ml |
2x to 3x per week, if possible prior to chemotherapy or antibiotics. At least 1x per week as adjuvant therapy or 2 to 3 series per year with 10 treatments each |
Major autohemotherapy | 15 - 25 µg/ml In general: 10 to max. 40 µg/ml |
50 ml | 2x to 3x per week, if possible prior to chemotherapy or antibiotics. At least 1x per week as adjuvant therapy or 2 to 3 series per year with 10 treatments each |
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