Jimoh, A.O.; Okwor, S.C.; Tukur, U.M.; Abubakar, B.; Hudu, S.A.; Sani, Z.; Mohammed, U.; Haruna, M.S.; Adeshina, K.A. Toxicological Evaluation and Central Nervous System Depressant Activities of Lizard Dung in Wistar Rats. Preprints2023, 2023091018. https://doi.org/10.20944/preprints202309.1018.v1
APA Style
Jimoh, A.O., Okwor, S.C., Tukur, U.M., Abubakar, B., Hudu, S.A., Sani, Z., Mohammed, U., Haruna, M.S., & Adeshina, K.A. (2023). Toxicological Evaluation and Central Nervous System Depressant Activities of Lizard Dung in Wistar Rats. Preprints. https://doi.org/10.20944/preprints202309.1018.v1
Chicago/Turabian Style
Jimoh, A.O., Muhammad Sanusi Haruna and Kehinde Ahmad Adeshina. 2023 "Toxicological Evaluation and Central Nervous System Depressant Activities of Lizard Dung in Wistar Rats" Preprints. https://doi.org/10.20944/preprints202309.1018.v1
Abstract
Though studies have characterized lizard dung as an unconventional psychoactive substance of abuse, this has not been demonstrated in experimental settings. We evaluated the toxicity and CNS activity of lizard dung in Wistar rats. The acute and subacute toxicity studies were conducted via oral and inhalational routes. Classical models of tail suspension, forced swim, elevated plus maze, hole board, and sodiumpentobarbital-induced sleeping time tests were adopted and the lizard dung were administered via both routes. No mortality was observed for all doses of the test substance administered via both routes during the toxicity studies. Significant changes in serum urea, creatinine, bilirubin, ALP, ALT and AST were recorded. Mixed inflammatory infiltrates and oedema were observed in the lungs from the group that inhaled 1.0g darkish part of lizard dung. Lizard dung produced marked reduction in the exploratory behaviour. Our findings indicate depression of the CNS.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
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