Version 1
: Received: 13 September 2023 / Approved: 14 September 2023 / Online: 15 September 2023 (04:54:38 CEST)
How to cite:
Gojani, E.G.; Wang, B.; Li, D.; Kovalchuk, O.; Kovalchuk, I. Effect of THC, CBD, THCV, CBC and CBN Cannabinoids on β-Cells Exposed to High Glucose—High Lipids. Preprints2023, 2023090973. https://doi.org/10.20944/preprints202309.0973.v1
Gojani, E.G.; Wang, B.; Li, D.; Kovalchuk, O.; Kovalchuk, I. Effect of THC, CBD, THCV, CBC and CBN Cannabinoids on β-Cells Exposed to High Glucose—High Lipids. Preprints 2023, 2023090973. https://doi.org/10.20944/preprints202309.0973.v1
Gojani, E.G.; Wang, B.; Li, D.; Kovalchuk, O.; Kovalchuk, I. Effect of THC, CBD, THCV, CBC and CBN Cannabinoids on β-Cells Exposed to High Glucose—High Lipids. Preprints2023, 2023090973. https://doi.org/10.20944/preprints202309.0973.v1
APA Style
Gojani, E.G., Wang, B., Li, D., Kovalchuk, O., & Kovalchuk, I. (2023). Effect of THC, CBD, THCV, CBC and CBN Cannabinoids on β-Cells Exposed to High Glucose—High Lipids. Preprints. https://doi.org/10.20944/preprints202309.0973.v1
Chicago/Turabian Style
Gojani, E.G., Olga Kovalchuk and Igor Kovalchuk. 2023 "Effect of THC, CBD, THCV, CBC and CBN Cannabinoids on β-Cells Exposed to High Glucose—High Lipids" Preprints. https://doi.org/10.20944/preprints202309.0973.v1
Abstract
Our findings indicate that all five phytocannabinoids reduce HG-HL-induced -cell loss likely through reducing apoptosis and pyroptosis. The protective effects of CBD, THCV, CBC, and CBN were seen in the GSIS impairment by HG-HL. Although all five phytocannabinoids tested in this research demonstrated the capability to inhibit β-cell dedifferentiation induced by HG-HL, CBD seems to be more effective compared to the other phytocannabinoids, as indicated by the specific biomarker responses of β-cells and progenitor cells to CBD.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
