Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Camille Blouet; Stéphanie Letast; Thomas Robert; Stéphane Bach; Noël Pinaud; Nicolas Joubert; Marie-Claude Viaud-Massuard; Jean Guillon; Cédric Logé; Caroline Denevault-Sabourin

doi:10.20944/preprints202309.0598.v1

A peer-reviewed article of this Preprint also exists.

Blouet, C.; Letast, S.; Robert, T.; Bach, S.; Pinaud, N.; Joubert, N.; Viaud-Massuard, M.-C.; Guillon, J.; Logé, C.; Denevault-Sabourin, C. Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.1^8,12.0^17,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate. Molbank 2023, 2023, M1735. Blouet, C.; Letast, S.; Robert, T.; Bach, S.; Pinaud, N.; Joubert, N.; Viaud-Massuard, M.-C.; Guillon, J.; Logé, C.; Denevault-Sabourin, C. Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate. Molbank 2023, 2023, M1735.

Abstract

Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway starting from commercially available 3-iodo-1,2-phenylenediamine. Structure characterization of this new substituted macrocyclic quinoxaline compound was achieved by using 1H NMR, 13C NMR, and HRMS spectral analysis. This new macrocyclic derivative demonstrated submicromolar potency on both Pim-1 and Pim-2 isoforms, with an interesting selectivity profile against a selected panel of human kinases.

Keywords

Subject

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Abstract

Keywords

Subject

Comments (0)