Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Probiotics on Pregnancy Outcomes in Gestational Diabetes: Systematic Review and Meta-analysis

Version 1 : Received: 6 September 2023 / Approved: 7 September 2023 / Online: 7 September 2023 (11:47:54 CEST)

A peer-reviewed article of this Preprint also exists.

Wu, R.; Luan, J.; Hu, J.; Li, Z. Effect of Probiotics on Pregnancy Outcomes in Gestational Diabetes: Systematic Review and Meta-Analysis. Archives of Gynecology and Obstetrics 2024, doi:10.1007/s00404-023-07346-5. Wu, R.; Luan, J.; Hu, J.; Li, Z. Effect of Probiotics on Pregnancy Outcomes in Gestational Diabetes: Systematic Review and Meta-Analysis. Archives of Gynecology and Obstetrics 2024, doi:10.1007/s00404-023-07346-5.

Abstract

Background: Gestational diabetes is a common complication during pregnancy that can lead to numerous adverse outcomes. Some studies suggest that probiotics may be used to treat gestational diabetes, however, the results remain controversial. We conducted a systematic review and meta-analysis to evaluate the effect of probiotics on blood glucose and pregnancy outcomes in women with gestational diabetes. Methods: A systematic search of PubMed, Embase, and Cochrane databases was performed (start date to August 22, 2023). Primary outcomes included fasting blood sugar (FBS), fasting serum insulin (FSI), homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI). Secondary outcomes included pregnancy and neonatal outcomes. Results: 15 articles (n = 1006 women) met the inclusion criteria and were included in the analysis. Compared to a placebo, probiotics can decrease FBS (MD -2.58, 95% CI -4.38 to -0.79, p < 0.01), FSI (MD -2.29, 95% CI -3.40 to -1.18, p < 0.01), HOMA-IR (MD -0.56, 95% CI -0.81 to -0.32, p < 0.01), birthweight (MD -101.20, 95% CI -184.62 to -17.77, p = 0.02), neonatal intensive care unit (NICU) (RR 0.60, 95% CI 0.40 to 0.89, p = 0.01), and hyperbilirubinemia (RR 0.31, 95% CI 0.16 to 0.61, p < 0.01), alongside higher QUICKI (MD 0.01, 95% CI 0.00 to 0.01, p < 0.01). However, no other significant results were obtained. Conclusion: Probiotics may improve blood glucose indicators and reduce neonatal hyperbilirubinemia, NICU admissions, and birth weight in women with GDM.

Keywords

probiotics; pregnancy; GDM; gestational diabetes; meta analysis

Subject

Medicine and Pharmacology, Dietetics and Nutrition

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