Mammalian Models in Alzheimer's Research: An update

Himadri Sharma; Keun-A Chang; John Hulme; Seong Soo A An

doi:10.20944/preprints202309.0365.v1

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preprints.org > medicine and pharmacology > neuroscience and neurology > doi: 10.20944/preprints202309.0365.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mammalian Models in Alzheimer's Research: An update

Version 1 : Received: 4 September 2023 / Approved: 6 September 2023 / Online: 6 September 2023 (04:02:36 CEST)

A peer-reviewed article of this Preprint also exists.

Sharma, H.; Chang, K.-A.; Hulme, J.; An, S.S.A. Mammalian Models in Alzheimer’s Research: An Update. Cells 2023, 12, 2459. Sharma, H.; Chang, K.-A.; Hulme, J.; An, S.S.A. Mammalian Models in Alzheimer’s Research: An Update. Cells 2023, 12, 2459.

Abstract

A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a complex multi-stage disease that currently afflicts over 50 million people worldwide. Unfortunately, previous therapeutic strategies developed from murine models emulating different aspects of AD pathogenesis have failed. Consequently, researchers are now developing models that express several aspects of pathogenesis that better reflect the clinical situation in humans. As such, this review seeks to provide insight regarding current applications of mammalian models in AD research by addressing recent developments and characterizations of prominent transgenic models and their contributions to pathogenesis as well as discuss the advantages, limitations, and application of emerging models (hAβ-KI) that better capture genetic heterogeneity and mixed pathologies observed in the clinical situation.

Keywords

Animal model; Alzheimer’s Disease; Amyloid β; Tau Protein; LOAD models; Transgenic Murine Models

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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