Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Zn–B–PLGA Biocomposite-Based Materials as Drug Delivery Systems: Research Progress

Maria Viorica Ciocîlteu
,
Ion Romulus Scorei
* ORCID logo ,
Gabriela Rău
,
Claudiu Nicolicescu
* ,
Andrei Biţă
,
Vladimir Lucian Ene
,
Andreea Simionescu
,
Adina Turcu-Ştiolică
,
Johny Neamţu
,
George Dan Mogoşanu
Version 1 : Received: 4 September 2023 / Approved: 5 September 2023 / Online: 5 September 2023 (10:03:29 CEST)

A peer-reviewed article of this Preprint also exists.

Ciocîlteu, M. V., Scorei, I. R., Rău, G., Nicolicescu, C., Biţă, A., Ene, V. L., ... & Mogoşanu, G. D. (2023). Zinc–Boron–PLGA biocomposite material: preparation, structural characterization, and in vitro assessment. Polymer, 7, 8. Ciocîlteu, M. V., Scorei, I. R., Rău, G., Nicolicescu, C., Biţă, A., Ene, V. L., ... & Mogoşanu, G. D. (2023). Zinc–Boron–PLGA biocomposite material: preparation, structural characterization, and in vitro assessment. Polymer, 7, 8.

Abstract

Our concern was to obtain a biocomposite material with improved properties of the constituent materials (poly(lactic- co-glycolic acid) (PLGA) and zinc–boron (Zn–B) complex) in accordance with the novelties in the field of delivery systems for therapeutic agents which lately redefine the importance of biopolymer nanocomposites with PLGA (biodegradable composites). The advantages of such a biomaterial target the health system, being easy to obtain, through a cost-effective method. The water/oil/water double emulsion method also allows the adjustment of the synthesis parameters, to maximize the degree of Zn–B complex encapsulation. The morphological aspects of the samples (size, shape, porosity) were established by scanning electron microscopy (SEM). Particle size distribution (by volume and by number) was determined by direct light scattering (DLS). For all the synthesized materials, the observed morphology was typical for PLGA, spherical one. The particle size distribution showed that depending on the synthesis conditions, the particles can be obtained with diameters between 10–450 nm range and the value of the zeta potential (ZP) shows that the particles have electronegative surface charge, which offers a favorable perspective on the phenomena of aggregation, flocculation, dispersion. It was observed, applying the design of experiments (DoE), that the size of the particles increased with increasing amounts of PLGA and polyvinyl alcohol (PVA) in the formulation, while ZP increased with higher PLGA and smaller PVA. The encapsulation efficiency was determined by ultra-high performance liquid chromatography/mass spectrometry (UHPLC/MS).

Keywords

Zn–B–PLGA biocomposite; DLS; SEM; DoE; UHPLC/MS

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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