Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes

Dong Yang; Yanfang Zhang; Ibrahima Sory Sow; Hongping Liang; Naima El Manssouri; Michel Gelbcke; Lina Dong; Guangxin Chen; François E. Dufrasne; Véronique Fontaine; Rongshan Li

doi:10.20944/preprints202309.0122.v1

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preprints.org > medicine and pharmacology > medicine and pharmacology > doi: 10.20944/preprints202309.0122.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes

Version 1 : Received: 31 August 2023 / Approved: 1 September 2023 / Online: 4 September 2023 (15:33:31 CEST)

A peer-reviewed article of this Preprint also exists.

Yang, D.; Zhang, Y.; Sow, I.S.; Liang, H.; El Manssouri, N.; Gelbcke, M.; Dong, L.; Chen, G.; Dufrasne, F.; Fontaine, V.; Li, R. Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes. Microorganisms 2023, 11, 2611. Yang, D.; Zhang, Y.; Sow, I.S.; Liang, H.; El Manssouri, N.; Gelbcke, M.; Dong, L.; Chen, G.; Dufrasne, F.; Fontaine, V.; Li, R. Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes. Microorganisms 2023, 11, 2611.

Abstract

Hydroxamic acid (HA) derivates displayed antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed to different metal ions Fe(II/III), Ni(II), Cu(II) and Zn(II) were evaluated for their antimycobacterial activities and their anti-biofilm activities. Some derivates, among others HA12Fe2, inhibited the development of Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium marinum biofilms and could even attack pre-formed Pseudomonas aeruginosa biofilm. Proteomic profiles showed that the potential targets of HA10FeCl were mainly related to mycobacteria stress adaptation, involving cell wall lipid biosynthesis, drug resistance and tolerance, siderophore metabolism. This study provides new insights regarding the antimycobacterial activities of the HA and their complexes, especially about their potential antibiofilm activities.

Keywords

Hydroxamic acids; Antibacterial; Anti-biofilm; Mycobacterium tuberculosis

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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