Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

IL1beta—Biomarker for Ischemic Stroke Prognosis and Carotid Atheromatosis

Gabriela Catana
* ORCID logo ,
Ioan-Adrian Popentiu
ORCID logo ,
Mădălina Văleanu
,
Corina Roman Filip
,
Romeo-Gabriel Mihăilă
Version 1 : Received: 30 August 2023 / Approved: 31 August 2023 / Online: 31 August 2023 (12:47:13 CEST)

A peer-reviewed article of this Preprint also exists.

Catană, M.-G.; Popențiu, I.-A.; Văleanu, M.; Roman-Filip, C.; Mihăilă, R.-G. IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery. Medicina 2023, 59, 1790. Catană, M.-G.; Popențiu, I.-A.; Văleanu, M.; Roman-Filip, C.; Mihăilă, R.-G. IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery. Medicina 2023, 59, 1790.

Abstract

Background and Objectives: Stroke is a main leading cause for mortality and morbidity worldwide. Treat-ment of this pathology is still under development and its risk factors remain the main target to be reached. Therefore, we aim to determine the role of interleukin 1 beta in atheromatosis, as risk factor for stroke and the reole of this biomarker in stroke prognosis. Materials and Methods: The study conducted enrolled 56 patients diagnosed with ischemic stroke in the anterior (AVT) and posterior vascular territory (PVT). All patients had venous blood collected at admission and 7 days after the onset of the cerebral ischemia in order to determine plasma concentration for interleukin 1 beta. At the same time an extracranial carotid ultrasound was performed. Results: Interleukin 1 beta collected at admission was positively correlated with NIHSS at admission (Pearson index 0,424) and both measurements were corelated with carotid stenosis (Spearmen correlation index 0,529, respectively 0,653). Conclusion: Interleukin 1 beta could be a reliable biomarker for stroke prognosis and carotid atheromatosis development.

Keywords

inflammation; stroke; atheromatosis; biomarker; interleukin 1 beta

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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