Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Electrochemical Sensors for Liquid Biopsy and Their Integration into Lab-on-Chip Platforms: Revolutionizing the Approach to Diseases

Salma Umme
* ORCID logo ,
Giulia Siciliano
,
Elisabetta Primiceri
,
Antonio Turco
ORCID logo ,
Iolena Tarantini
,
Francesco Ferrara
* ,
Maria Serena Chiriacò
ORCID logo
Version 1 : Received: 30 August 2023 / Approved: 31 August 2023 / Online: 31 August 2023 (10:40:48 CEST)

A peer-reviewed article of this Preprint also exists.

Umme, S.; Siciliano, G.; Primiceri, E.; Turco, A.; Tarantini, I.; Ferrara, F.; Chiriacò, M.S. Electrochemical Sensors for Liquid Biopsy and Their Integration into Lab-on-Chip Platforms: Revolutionizing the Approach to Diseases. Chemosensors 2023, 11, 517. Umme, S.; Siciliano, G.; Primiceri, E.; Turco, A.; Tarantini, I.; Ferrara, F.; Chiriacò, M.S. Electrochemical Sensors for Liquid Biopsy and Their Integration into Lab-on-Chip Platforms: Revolutionizing the Approach to Diseases. Chemosensors 2023, 11, 517.

Abstract

Screening and early diagnosis of diseases are crucial for a patient's treatment to be successful and to improve their survival rate, especially in cancer. The development of non-invasive analytical methods able to detect biomarkers of pathologies is a critical point to define a successful treat-ment and a good outcome. This study extensively reviews electrochemical methods used for the development of biosensors in liquid biopsy, owing to their ability to provide rapid response, pre-cise detection, and low detection limits. We also discuss new developments in electrochemical biosensors, which can improve the specificity and sensitivity of standard analytical procedures. Electrochemical biosensors demonstrate remarkable sensitivity in detecting minute quantities of analytes, encompassing proteins, nucleic acids, and circulating tumor cells, even within challeng-ing matrices such as urine, serum, blood, and various other body fluids. Among the various de-tection techniques used for the detection of cancer biomarkers, even in the picogram range, volt-ammetric sensors are deeply discussed in this review because of their advantages and technical characteristics. This widespread utilization stems from their ability to facilitate quantitative de-tection of ions and molecules with exceptional precision. The comparison of each electrochemical technique is discussed to provide the selection of appropriate analytical methods.

Keywords

Liquid biopsy; electrochemical sensors; Lab On Chip; miniaturization; sensors integration; microfabrication

Subject

Physical Sciences, Biophysics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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