Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

Christina Voycheva
ORCID logo ,
Marta Slavkova
* ORCID logo ,
Teodora Popova
,
Diana Tzankova
,
Denitsa Stefanova
,
Virginia Tzankova
,
Ivelina Ivanova
,
Stanislav Tzankov
,
Ivanka Spassova
ORCID logo ,
Daniela Kovacheva
ORCID logo ,
Borislav Tzankov
Version 1 : Received: 29 August 2023 / Approved: 30 August 2023 / Online: 31 August 2023 (12:35:42 CEST)

A peer-reviewed article of this Preprint also exists.

Voycheva, C.; Slavkova, M.; Popova, T.; Tzankova, D.; Stefanova, D.; Tzankova, V.; Ivanova, I.; Tzankov, S.; Spassova, I.; Kovacheva, D.; Tzankov, B. Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics. Gels 2023, 9, 769. Voycheva, C.; Slavkova, M.; Popova, T.; Tzankova, D.; Stefanova, D.; Tzankova, V.; Ivanova, I.; Tzankov, S.; Spassova, I.; Kovacheva, D.; Tzankov, B. Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics. Gels 2023, 9, 769.

Abstract

Hydrogels can offer many opportunities for drug delivery strategies. They can be used on their own or their benefits can be further exploited in combination with other nanocarriers. Intelligent hydrogels that react to changes in the surrounding environment can be utilized as gatekeepers and provide sustained on demand drug release. In this study, a hybrid nanosystem for tempera-ture and pH sensitive delivery was prepared from MCM-41 nanoparticles grafted with newly synthesized thermosensitive hydrogel (MCM-41/AA-g-PnVCL). The initial particles were chemi-cally modified by carboxyl groups attachment. Later, they were grafted with agar (AA) and vi-nylcaprolactam (VCL) by free radical polymerization. Doxorubicin was applied as a model hy-drophilic chemotherapeutic drug. The successful formulation was confirmed by FT-IR and TGA. Transmission electron microscopy and dynamic light scattering analysis showed small particles with negative zeta potential. Their release behaviour was investigated in vitro in different pH media and at different temperatures. At tumor simulating conditions (40ºC and pH 4.0) doxoru-bicin was almost completely released within 72 hours. The biocompatibility of the proposed na-noparticles was demonstrated by in vitro haemolysis assay. These results suggest the possible parenteral application of the newly prepared hydrogel-functionalized mesoporous silica nanopar-ticles for temperature-sensitive and pH-triggered drug delivery at the tumor site.

Keywords

Hydrogel gatekeeper; mesoporous silica nanoparticles; stimuli-sensitive delivery; chemotherapy; doxorubicin

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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