Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Risk of Drug Interactions in Older Primary Care Patients after Hospital Discharge; the Role of Drug Reconciliation

Cristina Vocca
ORCID logo ,
Antonio Siniscalchi
,
Vincenzo Rania
,
Cecilia Galati
,
Gianmarco Marcianò
,
Caterina Palleria
,
Luca Catarisano
,
Ilaria Gareri
,
Marco Leuzzi
,
Lucia Muraca
,
Rita Citraro
ORCID logo ,
Giacinto Nanci
,
Antonio Scuteri
,
Rosa Candida Bianco
,
Iolanda Fera
,
Antonietta Greco
,
Giacomo Leuzzi
,
Giovambattista De Sarro
ORCID logo ,
Bruno D'Agostino
,
Luca Gallelli
* ORCID logo
Version 1 : Received: 29 August 2023 / Approved: 30 August 2023 / Online: 30 August 2023 (05:14:49 CEST)

A peer-reviewed article of this Preprint also exists.

Vocca, C.; Siniscalchi, A.; Rania, V.; Galati, C.; Marcianò, G.; Palleria, C.; Catarisano, L.; Gareri, I.; Leuzzi, M.; Muraca, L.; Citraro, R.; Nanci, G.; Scuteri, A.; Bianco, R.C.; Fera, I.; Greco, A.; Leuzzi, G.; De Sarro, G.; D’Agostino, B.; Gallelli, L. The Risk of Drug Interactions in Older Primary Care Patients after Hospital Discharge: The Role of Drug Reconciliation. Geriatrics 2023, 8, 122. Vocca, C.; Siniscalchi, A.; Rania, V.; Galati, C.; Marcianò, G.; Palleria, C.; Catarisano, L.; Gareri, I.; Leuzzi, M.; Muraca, L.; Citraro, R.; Nanci, G.; Scuteri, A.; Bianco, R.C.; Fera, I.; Greco, A.; Leuzzi, G.; De Sarro, G.; D’Agostino, B.; Gallelli, L. The Risk of Drug Interactions in Older Primary Care Patients after Hospital Discharge: The Role of Drug Reconciliation. Geriatrics 2023, 8, 122.

Abstract

Introduction: Drug interactions (DDIs) represent an important clinical problem particularly in elderly patients due to polytherapy, comorbidity and physiological change in pharmacodynamic and pharmacokinetic pathways. In this study we investigated the association between drugs prescribed during hospital or clinical room discharge and the development of DDIs with drugs daily used from each patient. Methods: we performed an observational, retrospective, multicenter study on medical records of outpatients referred to general practitioners. Drug interactions (DDIs) were measured using the drug interactions probability scale. Collected data were analyzed using the Statistical Package for the Social Sciences. Results: During the study we evaluated 1,622 medical records. We recorded the development of DDIs in 10.3% of patients, of those 11.6% induced the hospitalization. Logistic regression showed an association between DDIs and sex and number of drugs used (P = 0.023). Conclusion: this real-life study shows that DDIs are common in elderly patients and physicians must take more attention after hospital discharge revaluating the treatment in order to reduce the risk of DDIs and hospitalization.

Keywords

reconciliation; deprescription; elderly; polytherapy

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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