Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Evolving Role of Stereotactic Body Radiation Therapy for Head and Neck Cancer: Where Do We Stand?

Issa Mohamad
ORCID logo ,
Irene Karam
,
Ahmed Elsehemy
,
Ibrahim Abu Gheida
,
Akram Al-Ibraheem
,
Hossam AL-Assaf
,
Mohammed Aldehaim
,
Majed Alghamdi
,
Ibrahim Alotain
,
May Ashour
,
Ahmad Bushehri
,
Mostafa Elhaddad
,
Ali Hosni
*
Version 1 : Received: 29 August 2023 / Approved: 29 August 2023 / Online: 30 August 2023 (05:09:50 CEST)

A peer-reviewed article of this Preprint also exists.

Mohamad, I.; Karam, I.; El-Sehemy, A.; Abu-Gheida, I.; Al-Ibraheem, A.; AL-Assaf, H.; Aldehaim, M.; Alghamdi, M.; Alotain, I.; Ashour, M.; Bushehri, A.; ElHaddad, M.; Hosni, A. The Evolving Role of Stereotactic Body Radiation Therapy for Head and Neck Cancer: Where Do We Stand? Cancers 2023, 15, 5010. Mohamad, I.; Karam, I.; El-Sehemy, A.; Abu-Gheida, I.; Al-Ibraheem, A.; AL-Assaf, H.; Aldehaim, M.; Alghamdi, M.; Alotain, I.; Ashour, M.; Bushehri, A.; ElHaddad, M.; Hosni, A. The Evolving Role of Stereotactic Body Radiation Therapy for Head and Neck Cancer: Where Do We Stand? Cancers 2023, 15, 5010.

Abstract

Stereotactic body radiation therapy (SBRT) is a precise and conformal radiation therapy (RT) that aims to deliver a high dose of radiation to the tumor with sparing surrounding normal tissue, making it an attractive option for head and neck cancer (HNC) patients who are not suitable for traditional long course of RT with comprehensive RT target volume. Definitive SBRT for HNC has been investigated in different settings, including early stage glottis cancer, and as alternative to brachytherapy boost after external beam RT. It also used as a primary treatment option for elderly or medically unfit patients. More recently, SBRT combination with immunotherapy in the neoadjuvant setting for HNC showed promising results. Salvage or adjuvant SBRT for HNC can be used in appropriately selected cases. Future studies are warranted to determine the optimum dose and fractionation schedules in any of these indications.

Keywords

head and neck cancer; SBRT; Hypofractionation

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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