Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Bioactive Endodontic Hydrogels: From Parameters to Personalized Medicine

Marianne Lévêque
,
Mourad Bekhouche
ORCID logo ,
Jean-Christophe Farges
ORCID logo ,
Audrey Aussel
,
Kadiatou Sy
,
Raphael Richert
ORCID logo ,
Maxime Ducret
*
Version 1 : Received: 25 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (08:45:41 CEST)

A peer-reviewed article of this Preprint also exists.

Leveque, M.; Bekhouche, M.; Farges, J.-C.; Aussel, A.; Sy, K.; Richert, R.; Ducret, M. Bioactive Endodontic Hydrogels: From Parameters to Personalized Medicine. Int. J. Mol. Sci. 2023, 24, 14056. Leveque, M.; Bekhouche, M.; Farges, J.-C.; Aussel, A.; Sy, K.; Richert, R.; Ducret, M. Bioactive Endodontic Hydrogels: From Parameters to Personalized Medicine. Int. J. Mol. Sci. 2023, 24, 14056.

Abstract

Regenerative endodontic procedures (REPs) aim at recreating dental pulp tissue using biomaterials such as hydrogels. Their bioactivity is mostly linked to the nature of biomolecules or chemical compounds that will compose the endodontic hydrogel. However, many other parameters, such as hydrogel concentration, type, bioactive molecules solubility, of apex size were reported to influence the hydrogel behavior, leading to the inability to predict the clinical outcome. This lack of knowledge and the various parameters that should be considered, suggest that biological activity of endodontic hydrogel is impossible to anticipate and could hinder the bench to bedside transition. We formulated in this article our opinion that most of these parameters could be identified, described, and studied. A second part of the document lists some challenges and perspectives, including development of future mathematical models able to explain and predict the bioactivity of these endodontic hydrogel in clinic.

Keywords

Regenerative endodontic procedures; hydrogels; tissue engineering; apical release; preclinical model

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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