Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of Clinical Outcomes after Poor-Quality Embryo Transfer and Prognostic Parameters

Version 1 : Received: 23 August 2023 / Approved: 24 August 2023 / Online: 25 August 2023 (07:11:04 CEST)

A peer-reviewed article of this Preprint also exists.

Kadioglu, N.; Kahyaoğlu, İ.; Kaplanoğlu, İ.; Dilbaz, S.; Engin Üstün, Y. Evaluation of Clinical Outcomes after Poor-Quality Embryo Transfer and Prognostic Parameters. J. Clin. Med. 2023, 12, 6236. Kadioglu, N.; Kahyaoğlu, İ.; Kaplanoğlu, İ.; Dilbaz, S.; Engin Üstün, Y. Evaluation of Clinical Outcomes after Poor-Quality Embryo Transfer and Prognostic Parameters. J. Clin. Med. 2023, 12, 6236.

Abstract

We aimed to investigate the clinical results following poor-quality embryo transfer and the parameters to foresee the prognosis. In this study, 2123 cycles that had day 3 and day 5 single-fresh embryo with a poor-quality embryo transfers and a good-quality embryo transfers were compared. The cycles according to transfer day were evaluated by conducting a subgroup analysis. The correlation between all the obtained demographic characteristics, controlled ovarian stimulation parameters and cycle results were analysed. Clinical pregnancy was established in 53 patients that underwent transfer in the poor-quality embryo group (14.9%). Of these patients, 36 had live birth (live birth rate per clinical pregnancy 67.9%). In cleavage-stage embryos, live birth rates per clinical pregnancy were higher in poor-quality blastocyst transfer. When analysing the factors affecting live births in poor-quality embryo group, as the total gonadotropin dose increases, the probability of live birth decreases, as in the probability of hCG positivity. In conclusion; although the probability of pregnant is low, when clinical pregnancy is established, there is a high chance of having a live birth after poor-quality embryo transfers. This could be regarded as an acceptable option in cycles when only poor-quality embryos were available.

Keywords

In vitro fertilization; gonadotropin dose; live birth rate; poor embryo quality

Subject

Medicine and Pharmacology, Reproductive Medicine

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