Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Foodomics-based Approaches Shed Light on the Potential Protective Effects of Polyphenols in Inflammatory Bowel Disease

Giovanni Pratelli
ORCID logo ,
Bartolo Tamburini
ORCID logo ,
Daniela Carlisi
ORCID logo ,
Anna De Blasio
ORCID logo ,
Antonella D'Anneo
ORCID logo ,
Sonia Emanuele
,
Antonietta Notaro
,
Federica Affranchi
,
Michela Giuliano
ORCID logo ,
Aurelio Seidita
ORCID logo ,
Marianna Lauricella
* ORCID logo ,
Diana Di Liberto
* ORCID logo
Version 1 : Received: 23 August 2023 / Approved: 23 August 2023 / Online: 25 August 2023 (04:55:30 CEST)

A peer-reviewed article of this Preprint also exists.

Pratelli, G.; Tamburini, B.; Carlisi, D.; De Blasio, A.; D’Anneo, A.; Emanuele, S.; Notaro, A.; Affranchi, F.; Giuliano, M.; Seidita, A.; Lauricella, M.; Di Liberto, D. Foodomics-Based Approaches Shed Light on the Potential Protective Effects of Polyphenols in Inflammatory Bowel Disease. Int. J. Mol. Sci. 2023, 24, 14619. Pratelli, G.; Tamburini, B.; Carlisi, D.; De Blasio, A.; D’Anneo, A.; Emanuele, S.; Notaro, A.; Affranchi, F.; Giuliano, M.; Seidita, A.; Lauricella, M.; Di Liberto, D. Foodomics-Based Approaches Shed Light on the Potential Protective Effects of Polyphenols in Inflammatory Bowel Disease. Int. J. Mol. Sci. 2023, 24, 14619.

Abstract

Inflammatory Bowel Disease (IBD) is a chronic and progressive inflammatory disorder affecting the gastrointestinal tract (GT) caused by a wide range of genetic, microbial, and environmental factors. IBD is characterized by chronic inflammation, decreased gut microbial diversity and dysbiosis, with a lower amount of beneficial bacteria and a concomitant increase of pathogenic species. It is well known that dysbiosis is closely related to the induction of inflammation and oxidative stress, this last caused by an imbalance between reactive oxygen species (ROS) production and cellular antioxidant capacity that leads to cellular ROS accumulation. ROS are responsible for the intestinal epithelium oxidative damage and the increased intestinal permeability found in IBD patients and their reduction could represent a potential therapeutic strategy to limit the IBD progression and alleviate its symptom. Recent evidence highlighted that dietary polyphenols, natural antioxidants, are able to maintain redox equilibrium in the GT preventing gut dysbiosis, intestinal epithelium damage and radical inflammatory responses. Here, we suggest that the relatively new foodomics approaches, together with new technologies for promoting the antioxidative properties of dietary polyphenols, including novel delivery systems, chemical modifications and combination strategies, may provide critical insight to determine the clinical value of polyphenols for IBD therapy and a comprehensive perspective for implementing natural antioxidants as potential IBD candidate treatment.

Keywords

inflammatory bowel diseases; omics; polyphenols; inflammation; antioxidative properties; gut dysbiosis

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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