Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Seroprevalence and associated Risks of Hepatitis E Virus Infection in an Epidemic Context in the Region of Kédougou, Southeast Senegal

Bacary Djilocalisse Sadio
* ,
Martin Faye
ORCID logo ,
Aboubacry Gaye
,
Cheikh T. Diagne
ORCID logo ,
Oumar Ndiaye
ORCID logo ,
Bocar Sow
,
Gamou Fall
ORCID logo ,
Oumar Faye
ORCID logo ,
Alassane Mbengue
,
Ousmane Faye
,
NDongo Dia
,
Amadou Alpha Sall
,
Abdourahmane Sow
Version 1 : Received: 18 August 2023 / Approved: 18 August 2023 / Online: 21 August 2023 (10:43:05 CEST)

How to cite: Sadio, B.D.; Faye, M.; Gaye, A.; Diagne, C.T.; Ndiaye, O.; Sow, B.; Fall, G.; Faye, O.; Mbengue, A.; Faye, O.; Dia, N.; Sall, A.A.; Sow, A. Seroprevalence and associated Risks of Hepatitis E Virus Infection in an Epidemic Context in the Region of Kédougou, Southeast Senegal. Preprints 2023, 2023081423. https://doi.org/10.20944/preprints202308.1423.v1 Sadio, B.D.; Faye, M.; Gaye, A.; Diagne, C.T.; Ndiaye, O.; Sow, B.; Fall, G.; Faye, O.; Mbengue, A.; Faye, O.; Dia, N.; Sall, A.A.; Sow, A. Seroprevalence and associated Risks of Hepatitis E Virus Infection in an Epidemic Context in the Region of Kédougou, Southeast Senegal. Preprints 2023, 2023081423. https://doi.org/10.20944/preprints202308.1423.v1

Abstract

Rapid proliferation of traditional gold mining sites in Kédougou a Southeast region in Senegal, led to mass population migration from the neighboring West African countries and rapid expansion of small mining villages with poor hygiene and sanitation conditions. An outbreak of hepatitis E was reported in 2014 with several cases of febrile jaundice among traditional mine workers. In this study, we analyzed both HEV IgM and IgG seroprevalence and the associated risk factors of infection by testing any suspected case and contacts collected from February 2012 to November 2014. RNA-negative sera from suspected cases and contacts were tested for anti-HEV IgM and anti-HEV IgG. A total of 799 sera were collected from 290 suspected cases, 470 contacts and 39 individuals with missing information. The median age of the cohort study was 19 years (1-88 years) with a male/female sex-ratio of 1.9. We found an overall prevalence of 43.68% (332/760) of anti-HEV IgM and 38.15% (290/760) of anti-HEV IgG sera. Our data provide new insights into the HEV epidemiology and point to the crucial need to estimate the disease’s burden in Kédougou and assess the viral mechanisms driving the disease’s severity in pregnant women.

Keywords

Hepatitis E Virus; seroprevalence; risk factors; mining gold villages; Southeastern Senegal

Subject

Public Health and Healthcare, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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