Preprint Short Note Version 1 Preserved in Portico This version is not peer-reviewed

2-((4-Amino-5-((2,4-Dichlorophenoxy)Methyl)-4H-1,2,4-Triazol-3-yl)Thio)-1-(5-Methyl-1-(4-Nitrophenyl)-1H-1,2,3-Triazol-4-yl)Ethan-1-One

Version 1 : Received: 18 August 2023 / Approved: 18 August 2023 / Online: 18 August 2023 (08:10:46 CEST)

A peer-reviewed article of this Preprint also exists.

Abdel-Wahab, B.F.; Mabied, A.F.; Fettinger, J.C.; Farahat, A.A. 2-((4-Amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one. Molbank 2023, 2023, M1720. Abdel-Wahab, B.F.; Mabied, A.F.; Fettinger, J.C.; Farahat, A.A. 2-((4-Amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one. Molbank 2023, 2023, M1720.

Abstract

The reaction of 2-bromo-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (1) with 4-amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazole-3-thiol (2) in absolute ethanol in the presence of triethyl amine as catalyst gave 2-((4-amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (3) in 73% yield. The structure of the title heterocycle (3) was confirmed by X-ray single crystal diffraction and spectral analyses (NMR and IR).

Keywords

1,2,3-triazole; 4-amino-1,2,4-triazole-3-thiol; condensation; heterocycles; crystal structure

Subject

Chemistry and Materials Science, Organic Chemistry

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