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Version 1
Preserved in Portico This version is not peer-reviewed
Carbon Ions for Hypoxic Tumors: Are We Taking the Most of It?
Version 1
: Received: 16 August 2023 / Approved: 17 August 2023 / Online: 18 August 2023 (09:58:14 CEST)
A peer-reviewed article of this Preprint also exists.
Sokol, O.; Durante, M. Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them? Cancers 2023, 15, 4494. Sokol, O.; Durante, M. Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them? Cancers 2023, 15, 4494.
Abstract
Hypoxia, associated with abnormal vessel growth, is a characteristic feature of many solid tumors that increases their metastatic potential and resistance to radiotherapy. Carbon ion radiation therapy, alone or in combination with other treatments, is one of the most promising treatments for hypoxic tumors because the oxygen enhancement ratio decreases with increasing particle LET. Nevertheless, the current clinical practice does not yet fully benefit from using carbon ions for tackling hypoxia. Here we give an overview of the existing experimental and clinical evidence supporting the efficacy of C-ion radiotherapy in overcoming hypoxia-induced radioresistance, followed by a discussion of the strategies proposed to enhance it, including different approaches to maximize the LET in the tumors.
Keywords
hipoxya; carbon ions; LET; particle therapy
Subject
Physical Sciences, Radiation and Radiography
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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