Version 1
: Received: 16 August 2023 / Approved: 17 August 2023 / Online: 18 August 2023 (07:24:37 CEST)
How to cite:
Gao, Z.; Kan, Y.; Xie, Y.; Guo, R.; Li, C.; Xu, Y.; Chu, J. A Review on Non-Leaching Antibacterial Bone Cement for Orthopaedic Surgery: From Past to Current Insights. Preprints2023, 2023081315. https://doi.org/10.20944/preprints202308.1315.v1
Gao, Z.; Kan, Y.; Xie, Y.; Guo, R.; Li, C.; Xu, Y.; Chu, J. A Review on Non-Leaching Antibacterial Bone Cement for Orthopaedic Surgery: From Past to Current Insights. Preprints 2023, 2023081315. https://doi.org/10.20944/preprints202308.1315.v1
Gao, Z.; Kan, Y.; Xie, Y.; Guo, R.; Li, C.; Xu, Y.; Chu, J. A Review on Non-Leaching Antibacterial Bone Cement for Orthopaedic Surgery: From Past to Current Insights. Preprints2023, 2023081315. https://doi.org/10.20944/preprints202308.1315.v1
APA Style
Gao, Z., Kan, Y., Xie, Y., Guo, R., Li, C., Xu, Y., & Chu, J. (2023). A Review on Non-Leaching Antibacterial Bone Cement for Orthopaedic Surgery: From Past to Current Insights. Preprints. https://doi.org/10.20944/preprints202308.1315.v1
Chicago/Turabian Style
Gao, Z., Yang Xu and Jian-Jun Chu. 2023 "A Review on Non-Leaching Antibacterial Bone Cement for Orthopaedic Surgery: From Past to Current Insights" Preprints. https://doi.org/10.20944/preprints202308.1315.v1
Abstract
Antibiotic-loaded bone cements are widely used in orthopedic surgery. However, they present issues such as a short antibiotic release time and the antibiotic resistance. These challenges necessitate the development of novel antibacterial bone cements. Non-leaching bone cement containing antibacterial motifs represents a promising advancement in this direction. Antibacterial motifs are incorporated into the cement either covalently or non-covalently, and while they will not be released, they will still exhibit surface antibacterial activity. This review comprehensively examines the structure and antimicrobial activity of prevalent non-leaching antimicrobial bone cements. Additionally, it delves into the characteristics of current methods employed for detecting surface antimicrobial activity. Finally, the future research direction of non-leaching antibacterial bone cement is discussed, with a specific focus on innovative antibacterial motifs, the mechanisms underlying non-leaching antibacterial properties, and the potential synergies achievable by combining non-leaching antibacterial bone cement with traditional antibiotics.
Keywords
non-leaching antibacterial bone cement; acrylic bone cement; contact-kill; biomaterials
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
