Version 1
: Received: 14 August 2023 / Approved: 15 August 2023 / Online: 16 August 2023 (03:18:46 CEST)
How to cite:
Shaban, R.; Radhwi, O.O.; Alharbi, N.; Jar, S.; Bajunaid, W.; Alzahrani, A.; Alhuzali, M.; Almarzouki, A.F. Prevalence and Significance of Elevated Cardiac Enzymes among Sickle Cell Disease Patients at King Abdulaziz University Hospital. Preprints2023, 2023081141. https://doi.org/10.20944/preprints202308.1141.v1
Shaban, R.; Radhwi, O.O.; Alharbi, N.; Jar, S.; Bajunaid, W.; Alzahrani, A.; Alhuzali, M.; Almarzouki, A.F. Prevalence and Significance of Elevated Cardiac Enzymes among Sickle Cell Disease Patients at King Abdulaziz University Hospital. Preprints 2023, 2023081141. https://doi.org/10.20944/preprints202308.1141.v1
Shaban, R.; Radhwi, O.O.; Alharbi, N.; Jar, S.; Bajunaid, W.; Alzahrani, A.; Alhuzali, M.; Almarzouki, A.F. Prevalence and Significance of Elevated Cardiac Enzymes among Sickle Cell Disease Patients at King Abdulaziz University Hospital. Preprints2023, 2023081141. https://doi.org/10.20944/preprints202308.1141.v1
APA Style
Shaban, R., Radhwi, O.O., Alharbi, N., Jar, S., Bajunaid, W., Alzahrani, A., Alhuzali, M., & Almarzouki, A.F. (2023). Prevalence and Significance of Elevated Cardiac Enzymes among Sickle Cell Disease Patients at King Abdulaziz University Hospital. Preprints. https://doi.org/10.20944/preprints202308.1141.v1
Chicago/Turabian Style
Shaban, R., Majed Alhuzali and Adel F. Almarzouki. 2023 "Prevalence and Significance of Elevated Cardiac Enzymes among Sickle Cell Disease Patients at King Abdulaziz University Hospital" Preprints. https://doi.org/10.20944/preprints202308.1141.v1
Abstract
Background: Millions of people worldwide suffer from a genetic hemoglobinopathy known as sickle cell disease (SCD). It is a long-term condition marked by progressive multiorgan failure. Among SCD patients, cardiovascular complications are the main leading cause of death. Cardiovascular complication raises cardiac markers level as well as sickle cell vaso-occlusive crisis (VOC). This makes it challenging to determine the source.
Methods: This research aims to identify the association between cardiac markers and myocardial infarction in SCD patients At King Abdulaziz University (KAUH) in Jeddah, Saudi Arabia. This retrospective study was conducted from June 2022 to March 2023. All patients with SCD who were 18 years and above were enrolled. Cardiac markers' associations with age, emergency room visits, ECG, blood transfusion, hydroxyurea, anticoagulants, and mortality were analyzed.
Result: 537 patient records were screened during the study period, of which 270 met the inclusion criteria. Among these, 144 (53.3%) were female. The prevalence of elevated LDH, troponin, and CK-MB among the SCD patients who visited ER for the VOC was 78.5%, 9.3%, and 6.3%, respectively. Overall, there was a significant relationship between the cardiac marker level and the number of ER visits, age and mortality (p= 0.01), but there was no significant association between the cardiac marker level and for each of the following: hydroxyurea use, antiplatelet/anticoagulant use, needing of blood transfusion and ECG abnormalities. This retrospective research shed light on the significance of cardiac marker levels in patients with SCD. The level of cardiac markers was remarkably linked with age, frequency of ER visits, and patients' states.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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