Submitted:
07 August 2023
Posted:
15 August 2023
Read the latest preprint version here
Abstract
Keywords:
1. Introduction and main result
2. Well posedness and uniform estimates
3. Two-scale convergence in thin heterogeneous domains
- (i)
- weakly two-scale converge in to if as ,for any (); we denote this by " in -weak ";
- (ii)
-
strongly two-scale converge in to if it is weakly two-scale convergent and furtherwe denote this by " in -strong ".(b) A sequence is said to weakly two-scale converge in to if, as ,for all that is Y-periodic in .
- (i)
- ;
- (ii)
- (i)
- in -weak ;
- (ii)
- in -strong ;
- (iii)
- is bounded in .
4. Derivation of the homogenized system
4.1. Preliminary results
4.2. Passage to the limit: Proof of the main result
4.3. Proof of Theorem 1
References
- Y. Achdou, B. Franchi, N. Marcello, M.C. Tesi, A qualitative model for aggregation and diffusion of beta-amyloid in Alzheimer’s disease, J. Math. Biol. 67(2013) 1369–1392. [CrossRef]
- H. Amann, Coagulation-fragmentation processes, Arch. Rat. Mech. Anal. 151(2000) 339–366.
- H. Amann, C. Walker, Local and global strong solutions to continuous coagulation-fragmentation equations with diffusion, J. Differ. Equ. 218 (2005) 159–186. [CrossRef]
- M. Anguiano, F.J. Suárez-Grau, Homogenization of an incompressible non-Newtonian flow through a thin porous medium, Z. Angew. Math. Phys. 68 (2017), 45. [CrossRef]
- M. Anguiano, F.J. Suárez-Grau, Derivation of a coupled Darcy-Reynolds equation for a fluid flow in a thin porous medium including a fissure, Zeit. Angew. Math. Phys. 68 (2017), 52. [CrossRef]
- M. Anguiano, R. Bunoiu, Homogenization of Bingham flow in thin porous media, Netw. Heter. Media 15 (2020) 87–110. [CrossRef]
- A. Bhattacharya, Homogenization and Multiscale Analysis of Electro-Diffusive Transport in Complex Media, PhD thesis, Friedrich-Alexander-Universität Erlangen-Nürnberg, 2023.
- A. Bhattacharya, M. Gahn, M. Neuss-Radu, Effective transmission conditions for reaction-diffusion processes in domains separated by thin channels, Appl. Anal. 101 (2022) 1896–1910. [CrossRef]
- G. Cardone, W. Jäger, J.L. Woukeng, Derivation and analysis of a non-local Hele-Shaw-Cahn-Hilliard system for flow in thin heterogeneous layers, Submitted.
- L. Cruz, B. Urbanc, S.V. Buldyrev, R. Christie, T. Gomez-Isla, S. Havlin, M. McNamara, H.E. Stanley, B.T. Hyman, Aggregation and disaggregation of senile plaques in Alzheimer disease, Proceed. Nat. Acad. Sci. 94 (1997) 7612–7616. [CrossRef]
- J. Fabricius, M. Gahn, Homogenization and dimension reduction of the Stokes-problem with Navier slip condition in thin perforated layers, arXiv preprint arXiv:2210.12052, 2022.
- B. Franchi, S. Lorenzani, From a microscopic to a macroscopic model for Alzheimer disease: two-scale homogenization of the Smoluchowski equation in perforated domains, J. Nonlin. Sci. 26 (2016) 717–753. [CrossRef]
- B. Franchi, S. Lorenzani, Smoluchowski equation with variable coefficients in perforated domains: homogenization and applications to mathematical models in medicine, In: Harmonic Analysis, PDE and Applications, pp 49–67, Springer, 2017.
- B. Franchi, M. C. Tesi, A qualitative model for aggregation fragmentation and diffusion of β-amyloid in Alzheimer’s disease, Rend. Semin. Mat. Univ. Politec. Torino 70 (2012) 75–84.
- M. Helal, E. Hingant, L. Pujo-Menjouet, G.F. Webb, Alzheimer’s disease: analysis of a mathematical model incorporating the role of prions, J. Math. Biol. 69 (2014) 1207–1235. [CrossRef]
- M. Gahn, M. Neuss-Radu, P. Knabner, Derivation of effective transmission conditions for domains separated by a membrane for different scaling of membrane diffusivity, Discrete Cont. Dyn. Syst. S 10 (2017) 773–797. [CrossRef]
- M. Gahn, M. Neuss-Radu, I.S. Pop, Homogenization of a reaction-diffusion-advection problem in an evolving micro-domain and including nonlinear boundary conditions, J. Differ. Equ. 289 (2021) 95–127. [CrossRef]
- M. Gahn, M. Neuss-Radu, P. Knabner, Effective interface conditions for processes through thin heterogeneous layers with nonlinear transmission at the microscopic bulk-layer interface, Network. Heter. Media 13 (2018) 609–640. [CrossRef]
- M. Gahn, W. Jäger, M. Neuss-Radu, Two-scale tools for homogenization and dimension reduction of perforated thin layers: Extensions, Korn-inequalities, and two-scale compactness of scale-dependent sets in Sobolev spaces, arXiv preprint arXiv:2112.00559, 2021.
- W. Jäger, J.L. Woukeng, Homogenization of Richards’ equations in multiscale porous media with soft inclusions, J. Differ. Equ. 281 (2021) 503–549. [CrossRef]
- W. Jäger, J.L. Woukeng, Sigma-convergence for thin heterogeneous domains and application to the upscaling of Darcy-Lapwood-Brinkmann flow, Submitted preprint, 2022.
- P. Laurençot, S. Mischler, Global existence for the discrete diffusive coagulation-fragmentation equations, Rev. Matem. Iberoamericana 18 (2002) 731–745. [CrossRef]
- S. Mischler, M.R. Ricard, Existence globale pour l’équation de Smoluchowski continue non homogène et comportement asymptotique des solutions, C. R. Math. 336 (2003) 407–412. [CrossRef]
- R.M. Murphy, M.M. Pallitto, Probing the kinetics of β-amyloid selfassociation, J. Struct. Biol. 130 (2000) 109–122. [CrossRef]
- M. Neuss-Radu, W. Jäger, Effective transmission conditions for reaction-diffusion processes in domains separated by an interface, SIAM J. Math. Anal. 39 (2007) 687–720. [CrossRef]
- A. Raj, A. Kuceyeski, M. Weiner, A network diffusion model of disease progression in dementia, Neuron 73 (2012) 1204–1215. [CrossRef]
- M. Sango, J.L. Woukeng, Stochastic sigma-convergence and applications, Dyn. PDE 8 (2011) 261–310.
- J.L. Woukeng, Homogenization in algebras with mean value, Banach J. Math. Anal. 9 (2015) 142–182. [CrossRef]
- D. Wrzosek, Existence of solutions for the discrete coagulation-fragmentation model with diffusion, Topological Meth. Nonlin. Anal. 9 (1997) 279–296. [CrossRef]
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