Submitted:
07 August 2023
Posted:
15 August 2023
Read the latest preprint version here
Abstract
We carry out in a thin heterogeneous porous layer, the multiscale analysis of a set of Smoluchowski's discrete diffusion-coagulation equations describing the evolution density of diffusion particles that are prone to coagulate in pairs. Assuming that the thin heterogeneous layer is made of microstructures that are uniformly distributed inside, we obtain in the limit an upscaled model in lower space dimension. To achieve our goal, we use the concept of two-scale convergence adapted to thin heterogeneous media.
Keywords:
Homogenizatio
; Smoluchowski equation
; two-scale convergence
; thin domains
1. Introduction and main result
The Smoluchowski equation modeling Alzheimzer’s disease (AD) is a system of partial differential equations that describes the evolving densities of diffusing particles that are prone to coagulate in pairs. Recently, the important role of Smoluchowski equation in modeling the evolution of AD at different scales has been investigated in [1,12,14,29] in which the authors presented a mathematical model for the aggregation and diffusion of -amyloid (A) in the brain affected by AD at a microscopic scale (the size of a single neuron) and at the early stage of the disease when small amyloid fibrils are free to move and to coalesce. We also refer to [2,3,10,15,22,23,24,26] for some other works in the same direction. In the model proposed in [12], a very small portion of the cerebral tissue is described by a bounded smooth region which is perforated by removing from it a set of periodically distributed holes of size (the neurons). Moreover the production of A in monomeric form at the level of neuron membranes is modeled by a non homogeneous Neumann condition on the boundary of the porosities.
In the current work, we consider the model stated in [12], but this time in a thin porous layer. This is motivated by the fact that Alzheimer’s disease particularly affects the cerebral cortex (responsible for language and information processing) and hippocampus (essential for memory), which represent very thin layers of brain tissue and contain thousands millions of neurons. Here we describe a very small layer of the brain tissue by a highly heterogeneous thin porous layer in which the heterogeneities are due to the number of millions of neurons that the brain tissue can contain. To be more precise, our model problem at the micro level is stated below.
Let be a bounded open Lipschitz connected subset in . For be freely fixed, we set
We denote by the reference layer cell, where and . Let be a compact set in Z with smooth boundary, which represents a generic neuron, and let be the supporting cerebral tissue (often call the solid part in the literature of porous media). Next, let , and set . We define the thin porous layer by
The boundary of is divided into two parts: the outer boundary and the inner boundary . We also denote by , so that . Finally we denote by the outward unit normal to . We assume that is connected and that , where stands for the Lebesgue measure of in . The -model reads as follows: for , solves the PDE
for , solves the PDE
and for , solves the equation
where
We assume that:
H1. the coefficients are positive constants and satisfy () with , and that the diffusion coefficients are positive constants that become smaller as j is large.
H2. The function is defined by (), where with and for .
In (H2), denotes the space of functions in that are Y-periodic. In (1)-(3), ∇ stands for the usual gradient operator while denotes the divergence operator with respect to the variable x; T is a positive number representing the final time. The unknowns are the vectors value functions , where the coordinate () stands for the concentration of m-clusters, that is clusters made of m identical elementary particles, while takes into account aggregation of more than monomers. It is worth noting that the meaning of is different from that of () as it aims at describing the sum of densities of all the large assemblies. It is assumed that the large assemblies exhibit all the same coagulation properties and do not coagulate with each other. We also assume that the only reaction allowing clusters to form large clusters is a binary coagulation mechanism, while the movement of clusters leading to aggregation arises only from a diffusion process described by the constant diffusion coefficient (). The kinetic coefficient arises from a reaction in which an -cluster is formed from an i-cluster and a j-cluster. Therefore, they can be interpreted as coagulation rates. Finally, () accounts for the formation of m-clusters by coalescence of smaller clusters and accounts for the formation of a large clusters by coalescence of others large one that have the same coagulation properties.
Our main aim in this work is to investigate the limiting behaviour as , of the solution to (1)-(3) under the assumptions (H1)-(H2). This falls within the scope of the homogenization theory in thin porous domains.
There is a huge literature on homogenization in fixed or porous media. A few works deal with the homogenization theory in thin heterogeneous domains; see e.g. [4,5,6,8,9,11,16,17,18,21,25]. As for the homogenization in thin heterogeneous porous media, very few results are known up to now. We may cite [4,5,6,8,11]. Concerning the Smoluchowski equation as stated in this work, to the best of our knowledge, the only work dealing with its homogenization is the paper [12] in which the considered domain is a uniformly perforated one that is not thin. Because our domain is thin and porous, the homogenization process is not an easy task. Indeed, we make use of the partial mean integral operator (see below for its definition) associated to the extension operator, while in [12], even the extension operator is not used. So, the main novelty in our work arises from the fact that the domain is a thin heterogeneous porous layer. This leads to a dimension reduction problem in the limit as shown here below in the main result, which reads as follows.
Theorem 1.
Assume that (H1)-(H2) hold. For any , let be the unique solution of (1)-(3) in the class , (). Let also and denote respectively the partial mean integral operator and the extension operator defined by (34) (see Section 3) and in Lemma 3 (see Section 2). Then, as , one has, for any ,
where is the unique solution of the system (8)-(10) below:
If ,
and
Moreover and is such that
In (8)-(10), n is the outward unit normal to and the matrix , where is the identity matrix and with being the unique solution in is Y-periodic and of the cell problem
where here, ν stands for the outward unit normal to Γ and is the ith vector of the canonical basis in ; the function and θ are defined respectively by , and (the Lebesgue measure of in .
The partial mean integral considered in Theorem 1 is defined, for a function by
The system (8)-(10) is the upscaled model arising from the -model (1)-(3). It is posed in a 2 dimensions space, leading to an expected dimension reduction problem as it is usually the case for the homogenization theory in thin domains. Moreover the information given on the microscale by the Neumann boundary condition in (1) is transferred (in the limit) into the source term in the leading equation in (8), so that, in the case of (1), the limiting equation does not have the same form as the original equation posed in the -model. For (9) and (10), apart from the diffusion term, they are similar to the -equations in (2) and (3).
The rest of the paper is organized as follows. In Section 2, we investigate the well posedness of (1)-(3) and provide useful uniform estimates. Section 3 deals with the treatment of the concept of two-scale convergence for thin heterogeneous domains. We prove therein some compactness results that will be used in the homogenization process. With the help of the results obtained in Section 3, we pass to the limit in (1)-(3) in Section 4 where we prove the main result, viz. Theorem 1.
2. Well posedness and uniform estimates
The current section deals with the existence and uniqueness of the solution to (1)-(3), together with some uniform estimates that will be useful in the sequel. The following result holds true.
Theorem 2.
Proof.
The well posedness of (1)-(3) has been addressed in [1,12,13,29]. We are concerned here only with the uniform estimates (12)-(14), the estimate (15) being a classical result arising from the trace result. We just emphasize that since ( stands for the Lebesgue measure of ), no scaling is needed in the left-hand side of (15). Now, as for (12), we follows exactly the same lines of reasoning as in [12] to obtain it. It remains to check (13) and (14). We first consider (13). We distinguish the cases and .
We start with . Multiplying (1) by and integrating over , next using the divergence theorem, we get
where the last inequality above stems from Hölder’s and Young’s inequalities. We use a well-known trace inequality to deduce the existence of a positive constant independent of such that
Therefore, integrating (16) over () and taking into account (15) and (17), we are led to
We therefore infer the boundedness of in associated to (18) that there exists such that (13) holds for and for all , where is chosen such that , that is, .
For , we proceed as for and multiply (2) by and integrate over ; then one obtains
Integrating over for , we get
Using (12), we get at once
Finally, the proof of (13) for is obtained exactly as the one for the case mutatis mutandis (replace by ).
Let us now prove (14). We proceed as above by distinguishing three cases.
For , we multiply (1) by and use (1)-(1) to get
But
Thus
Integrating (19) over and using the boundedness property (12), we obtain after integration by parts,
where we have used the fact that . Now, we use the inequality (17); then (20) becomes
It follows that
where in (21), we took advantage of (12) and (13). Hence, choosing sufficiently small so that , we get (14) for .
The proof of (14) in the case when follows the same lines of reasoning as above, but is much easier. It is therefore left to the reader. This completes the proof. □
The following result whose proof can be found in [19, Theorem 3] will be useful in the sequel.
Lemma 3.
There exists a bounded linear operator such that, for all , in and
and
for a positive constant independent of both ε and v.
Based on Lemma 3, we define the extension of a function to as follows:
Then accounting of Lemma 3 and Theorem 2, we have
where is independent of and
We also need an estimate on in . To that end, we procced as in [20] and consider the restriction operator , (the restriction of v to ). Then it is a fact that is a bounded linear operator as
Now, if denotes the adjoint operator of , then for , we define as follows:
and we have
for all and . It is therefore easy to see that for all , or equivalently
Lemma 4.
Let the assumptions of Theorem 2 hold. It holds that
where is independent of ε, and is defined in Theorem 2.
Proof.
First, we have , where . Thus it is sufficient to show that
So, let ; then
Whence the result. □
3. Two-scale convergence in thin heterogeneous domains
The two-scale convergence for thin heterogeneous domains has been introduced in [25] and extended to thin porous surfaces in [8,19]. The notations used in this section are the same as in the previous ones. Especially, the domain is defined as above, that is, . When , shrinks to the "interface" . We know that and , and we set , , and finally . Let ; by we denote the space of functions in that are Y-periodic. Accordingly we define as the subspace of made of periodic Y-periodic functions, and we set
which is a Banach space equipped with the norm
Any x in writes or where . We identify with so that the generic element in is also denoted by instead of .
We are now able to define the two-scale convergence for thin heterogeneous domains and for thin boundaries.
Definition 5.
(a) A sequence () is said to
- (i)
- weakly two-scale converge in to if as ,for any (); we denote this by " in -weak ";
- (ii)
-
strongly two-scale converge in to if it is weakly two-scale convergent and furtherwe denote this by " in -strong ".(b) A sequence is said to weakly two-scale converge in to if, as ,for all that is Y-periodic in .
Remark 6.
It is easy to see that if then (26) is equivalent to
where for .
We start with the following important result that should be used in the sequel; see [7, Lemma 3.2.3] for the proof.
Lemma 7.
Let that is Y-periodic in . Then, letting for , we have
- (i)
- ;
- (ii)
Throughout the work, the letter E will stand for any ordinary sequence with and when . The generic term of E will be merely denote by and will mean as . This being so, we have the following compactness results.
Theorem 8.
(i) Let be a sequence in such that
where C is a positive constant independent of ε. Then there exists a subsequence of E such that the sequence weakly two-scale converges in to some .
(ii) Let be a sequence in such that
being independent of ε. Then there exist a subsequence of E and a function such that, as ,
Proof.
Theorem 9.
Let be a sequence in () such that
where is independent of ε. Then there exist a subsequence of E and a couple with and such that, as ,
and
Proof.
See [16] for the proof. □
The following result is sharper than its homologue in Theorem 9.
Theorem 11.
Let be a sequence in such that
where C is a positive constant independent of ε. Finally, suppose that the embedding is compact. Then there exist a subsequence of E and a couple such that, as ,
and
Proof.
First, owing to Theorem 9, there exist a subsequence of E and a couple such that, as ,
and
It remains to prove (31). To that end, we set
Then we easily see that with
Then from (35), we derive the existence of a subsequence of still denoted by and of a function such that, as ,
We recall that (36) stems from the compactness of the embedding .
The next result and its corollary are proved exactly as their homologues in [27, Theorem 6 and Corollary 5] (see also [28]).
Theorem 12.
Let and be such that . Assume is weakly two-scale convergent in to some , and is strongly two-scale convergent in to some . Then the sequence is weakly two-scale convergent in to .
Corollary 13.
Let and ( and ) be two sequences such that:
- (i)
- in -weak ;
- (ii)
- in -strong ;
- (iii)
- is bounded in .
Then in -weak .
4. Derivation of the homogenized system
4.1. Preliminary results
In this subsection, we aim at providing further important convergence results that will be very useful in the sequel. In that order, it is to be noted that can alternatively be defined as follows: , where with . We set , a periodic repetition of the set . We denote by the characteristic function function of in : . Then it holds that
so that for .
Lemma 14.
Let be a sequence in () that weakly two-scale converges in towards . Then, as ,
If further the two-scale convergence is strong, then (38) holds in the strong two-scale sense.
Proof.
Set for . Then since in -weak , it holds that ( being independent of ), so that . Hence, up to a subsequence, in in the usual classical two-scale weak sense, where . Next, let . Passing to the limit (in the subsequence determined above) in the obvious equality
we get at once .
This being so, choosing f as above, one has
Owing to the usual two-scale concept, we obtain, as ,
where in (39) we have used the fact that proved above. This concludes the proof. □
The following result will be crucial in the homogenization process. From now on, we set , the characteristic function of in Z.
Proposition 15.
4.2. Passage to the limit: Proof of the main result
Assume that the functions and are as in Proposition 15. Let and , and define
We as test function in the variational form of (1)-(3):
For ,
and
Let us first deal with (47). We note that it is equivalent to
We have that
Thus we may apply Proposition 15 to pass to the limit in the first two terms on the left-hand side of (50), using as test function in the two-scale concept. As for the term on the right-hand side of (50), we use Lemma 7 to pass to the limit therein. We end up with the last term on the left-hand side where the limit passage therein is more involved. Indeed, we use there the strong two-scale convergence of towards associated to the weak two-scale convergence of () towards to get from Corollary 13 that, for , we have, as ,
Therefore, using in that term the test function and taking into account all the process described above after (50), we are led, as in (50), to
We use the same process as for (50) to pass to the limit in (48) and in (49), and we obtain:
For ,
and
We have proved the following result.
Theorem 16.
Our next goal is to derive the system whose is solution to. To that end, we start by uncoupling each of the equations (51)-(53). We first consider (51) and we see that it is equivalent to the following system consisting of (54) and (55) below:
Let us first consider Eq. (54) and choose therein under the form with and ; then (54) becomes
To solve (56), we rather consider the variation problem
where () denotes the jth vector of the canonical basis of . Then (57) is equivalent to the cell problem
where stands for the outward unit normal to . It is well known that (58) possesses a unique solution in the space
Now, multiplying (57) by () and summing up the resulting equations, then comparing the latter sum with (56) yields at once
where .
Next, going back to (55) and replacing there by the expression obtained in (59), we get
where is the identity matrix.
This being so, we set
Then A is a symmetric positive definite matrix. Indeed it is a fact that the entries of A have the form
this stems from (57) where we show that it is still valid for and the choose therein . With the above notations in (61), we see that (60) is equivalent to the problem
Proceeding as we did for (51), we easily show that (52) and (53) are equivalent to the variational formulations of the following PDEs:
4.3. Proof of Theorem 1
The proof of (5)-(7) follows easily from (44)-(46) associated to the properties of the operator Mε. The fact that (um)1≤m≤M solves (8)-(10) has been shown here above in Subsection 4.2. Now, if we proceed as in [1] (see also [12]), we get the wellposedness of (8)-(10) in the space , and especially, (11) holds true. Finally, the fact that the whole sequence converges towards (um)1≤m≤M follows from the uniqueness of the solution (8)-(10). This concludes the proof.
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