Menegucci, T.; Chagas, E.F.B.; de Oliveira Zanuso, B.; Quesada, K.; dos Santos Haber, J.F.; Menegucci Zutin, T.L.; Felipe Pimenta, L.; Cressoni Araújo, A.; Landgraf Guiguer, E.; Rucco P. Detregiachi, C.; Gabaldi Rocha, M.; Cincotto dos Santos Bueno, P.; Fornari Laurindo, L.; Barbalho, S.M. The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus. Diseases2023, 11, 125.
Menegucci, T.; Chagas, E.F.B.; de Oliveira Zanuso, B.; Quesada, K.; dos Santos Haber, J.F.; Menegucci Zutin, T.L.; Felipe Pimenta, L.; Cressoni Araújo, A.; Landgraf Guiguer, E.; Rucco P. Detregiachi, C.; Gabaldi Rocha, M.; Cincotto dos Santos Bueno, P.; Fornari Laurindo, L.; Barbalho, S.M. The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus. Diseases 2023, 11, 125.
Menegucci, T.; Chagas, E.F.B.; de Oliveira Zanuso, B.; Quesada, K.; dos Santos Haber, J.F.; Menegucci Zutin, T.L.; Felipe Pimenta, L.; Cressoni Araújo, A.; Landgraf Guiguer, E.; Rucco P. Detregiachi, C.; Gabaldi Rocha, M.; Cincotto dos Santos Bueno, P.; Fornari Laurindo, L.; Barbalho, S.M. The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus. Diseases2023, 11, 125.
Menegucci, T.; Chagas, E.F.B.; de Oliveira Zanuso, B.; Quesada, K.; dos Santos Haber, J.F.; Menegucci Zutin, T.L.; Felipe Pimenta, L.; Cressoni Araújo, A.; Landgraf Guiguer, E.; Rucco P. Detregiachi, C.; Gabaldi Rocha, M.; Cincotto dos Santos Bueno, P.; Fornari Laurindo, L.; Barbalho, S.M. The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus. Diseases 2023, 11, 125.
Abstract
Glycated hemoglobin (HbA1c) is used to assess glycemic control in Type 1 diabetes (DM1) patients. Apolipoproteins play an essential role in DM1 pathophysiology and may be associated with complications, as well as HbA1c. This cross-sectional observational study consisting of 81 children and adolescents of both sexes diagnosed with DM1 investigated the relationship between body fat distribution and lean mass with HbA1C and apolipoprotein values analyzing biochemical and body composition measurements. Shapiro-Wilk test with Lilliefors correction, non-parametric Mann-Whitney test, and others were used with a significance level of 5%. The sample had a diagnosis time of 4.32 years and high blood glucose levels (mean 178.19 mg/dL) and HbA1c (mean 8.57%). Subjects also had a moderate level of adiposity, as indicated by arm and thigh fat areas. The study also found significant differences in the distribution of patients concerning levels of apolipoproteins A and B, with a smaller proportion of patients having undesirable levels. Finally, the study found a significant difference in the distribution of patients with estimated cardiovascular risk based on the ApoB/ApoA-1 ratio. Conclusively, visceral fat in children and adolescents with DM1 may increase the risk of DM1 long-term complications owing to its association with elevated HbA1C and apolipoprotein values.
Keywords
Type 1 Diabetes Mellitus; body fat; lean mass; glycated hemoglobin; apolipoprotein.
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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