Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Therapeutic Effect of Nepenthes kampotiana Lecomte Ethanol Extract (Nk-EE) on Androgenic Alopecia through the Inhibition of Apoptosis and 5a-Reductase Activity

Dong Seon Kim
,
Won Young Jang
ORCID logo ,
Sang Hee Park
ORCID logo ,
Ji Hye Yoon
,
Chae Yun Shin
,
Lei Huang
,
Kry Masphal
,
Chhang Phourin
,
Hye-Woo Byun
,
Jino Son
,
Ga Ryun Kim
,
Byoung-Hee Lee
ORCID logo ,
Jong-Hoon Kim
* ,
Jongsung Lee
* ORCID logo ,
Jae Youl Cho
* ORCID logo
Version 1 : Received: 9 August 2023 / Approved: 9 August 2023 / Online: 10 August 2023 (10:48:25 CEST)

How to cite: Kim, D.S.; Jang, W.Y.; Park, S.H.; Yoon, J.H.; Shin, C.Y.; Huang, L.; Masphal, K.; Phourin, C.; Byun, H.; Son, J.; Kim, G.R.; Lee, B.; Kim, J.; Lee, J.; Cho, J.Y. Therapeutic Effect of Nepenthes kampotiana Lecomte Ethanol Extract (Nk-EE) on Androgenic Alopecia through the Inhibition of Apoptosis and 5a-Reductase Activity. Preprints 2023, 2023080811. https://doi.org/10.20944/preprints202308.0811.v1 Kim, D.S.; Jang, W.Y.; Park, S.H.; Yoon, J.H.; Shin, C.Y.; Huang, L.; Masphal, K.; Phourin, C.; Byun, H.; Son, J.; Kim, G.R.; Lee, B.; Kim, J.; Lee, J.; Cho, J.Y. Therapeutic Effect of Nepenthes kampotiana Lecomte Ethanol Extract (Nk-EE) on Androgenic Alopecia through the Inhibition of Apoptosis and 5a-Reductase Activity. Preprints 2023, 2023080811. https://doi.org/10.20944/preprints202308.0811.v1

Abstract

Alopecia refers to the continuous shedding of hair from the scalp or other areas. Genetic factors are the most common of the variety of causes of alopecia. Male pattern baldness, also known as androgenic alopecia, is prevalent. Recently, the interest in hair loss treatment has increased due to the growing number of people experiencing anxiety and stress related to hair loss. Nepenthes kampotiana Lecomte is known for its anticancer effects, but its potential for preventing hair loss has not been researched. Therefore, this study focused on the hair loss prevention effects of N. kampotiana Lecomte ethanol extract (Nk-EE). The results showed that Nk-EE has a proliferative effect on human follicle dermal papilla cells and inhibited cell death. In vivo experiments using androgenic areata models showed that Nk-EE had a positive effect on a variety of biomarkers such as hair-to-skin ratio, hair type frequency, and hair thickness. The results of this study suggest that Nk-EE has the potential to be an effective treatment for androgenic alopecia.

Keywords

Alopecia areata; Nepenthes Kampotiana Lecomte; 5a-reductase; testosterone

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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