Review
Version 2
Preserved in Portico This version is not peer-reviewed
Untousling the Role of Tousled like Kinase 1 in DNA Damage Repair
Version 1
: Received: 7 August 2023 / Approved: 9 August 2023 / Online: 9 August 2023 (07:05:21 CEST)
Version 2 : Received: 28 August 2023 / Approved: 29 August 2023 / Online: 30 August 2023 (05:08:39 CEST)
Version 2 : Received: 28 August 2023 / Approved: 29 August 2023 / Online: 30 August 2023 (05:08:39 CEST)
A peer-reviewed article of this Preprint also exists.
Ghosh, I.; De Benedetti, A. Untousling the Role of Tousled-like Kinase 1 in DNA Damage Repair. Int. J. Mol. Sci. 2023, 24, 13369. Ghosh, I.; De Benedetti, A. Untousling the Role of Tousled-like Kinase 1 in DNA Damage Repair. Int. J. Mol. Sci. 2023, 24, 13369.
Abstract
DNA damage repair lies at the core of all cells’ survival strategy, including cancerous. Therefore, targeting such repair mechanisms forms the major goal of cancer therapeutics. The mechanism of DNA repair has been tousled with the discovery of multiple kinases. Recent studies on Tousled like Kinases have brought significant clarity on the effectors of these kinases which stands to regulate DSB repair. In addition to their well-established role in the DDR and cell cycle checkpoint mediation after DNA damage or inhibitors of replication, their suspected involvement in the actual DSB repair process has more recently been strengthened by the important finding that TLK1 phosphorylates RAD54 and regulates some of its activities and localization in the cell. Earlier findings of its regulation of RAD9 during checkpoint deactivation as well as defined steps during NHEJ ends processing were earlier hints of its important involvement broadly in DSB repair. All this has opened up new avenues to target cancer cells in combination therapy with genotoxins and TLK inhibitors.
Keywords
TLKs; DNA repair; HRR; NHEJ; replication; DNA damage; therapeutics
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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