Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preventive Effect of Molecular Iodine in Pancreatic Disorders from Hypothyroid Rabbits

Julia Rodríguez-Castelán
ORCID logo ,
Evangelina Delgado-González
ORCID logo ,
Esteban Rodriguez-Benitez
,
Francisco Castelan
,
Estela Cuevas-Romero
ORCID logo ,
Brenda Anguiano
,
Carmen Aceves
* ORCID logo
Version 1 : Received: 8 August 2023 / Approved: 8 August 2023 / Online: 8 August 2023 (08:37:22 CEST)

A peer-reviewed article of this Preprint also exists.

Rodríguez-Castelán, J.; Delgado-González, E.; Rodríguez-Benítez, E.; Castelán, F.; Cuevas-Romero, E.; Anguiano, B.; Jeziorski, M.C.; Aceves, C. Preventive Effect of Molecular Iodine in Pancreatic Disorders from Hypothyroid Rabbits. Int. J. Mol. Sci. 2023, 24, 14903. Rodríguez-Castelán, J.; Delgado-González, E.; Rodríguez-Benítez, E.; Castelán, F.; Cuevas-Romero, E.; Anguiano, B.; Jeziorski, M.C.; Aceves, C. Preventive Effect of Molecular Iodine in Pancreatic Disorders from Hypothyroid Rabbits. Int. J. Mol. Sci. 2023, 24, 14903.

Abstract

Pancreatic alterations like inflammation and insulin resistance accompany hypothyroidism. Molecular iodine (I2) exerts antioxidant and differentiation actions in several tissues, and the pancreas is an iodine-uptake tissue. We analyzed the effect of two oral I2 doses on pancreatic disorders in a model of hypothyroidism for 30 days. Adult female rabbits were divided into the following groups: control, moderate oral dose of I2 (0.2 mg/kg, M-I2), high oral dose of I2 (2.0 mg/kg, H-I2), oral dose of methimazole (MMI; 10 mg/kg), MMI+M-I2, and MMI+H-I2. Moderate or high I2 supplementation did not modify circulating metabolites or pancreatic morphology. The MMI group showed circulating reductions of thyroxine (T4) and triiodo-thyronine (T3), moderate glucose increments, and significant increases in cholesterol and low-density lipoproteins. Acinar fibrosis, high insulin content, lipoperoxidation, and over-expression of GLUT4 were observed in the pancreas of this group. M-I2 supplementation normalized the T4 and cholesterol, but T3 remained low. Pancreatic alterations were prevented, nuclear factor erythroid-2-related factor-2 (Nrf2), antioxidant enzymes, and peroxisome proliferator-activated receptor gamma (PPARG) maintained their basal values. In MMI+H-I2, hypothyroidism was avoided, but pancreatic alterations and low PPARG expression remained. In conclusion, M-I2 supplementation reestablishes thyronine synthesis and diminishes pancreatic alterations, possibly related to Nrf2 and PPARG activation.

Keywords

iodine; pancreatitis; hypothyroidism; rabbits

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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