Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles

Aslan Mussin
,
Ali Al-Julaih
,
Neli Mintcheva
ORCID logo ,
Delvin Aman
ORCID logo ,
Satoru Iwamori
,
Stanislav O. Gurbatov
,
Abhishek Bhardwaj
,
Sergei A. Kulinich
* ORCID logo
Version 1 : Received: 4 August 2023 / Approved: 4 August 2023 / Online: 7 August 2023 (10:49:10 CEST)

A peer-reviewed article of this Preprint also exists.

Mussin, A.; AlJulaih, A.A.; Mintcheva, N.; Aman, D.; Iwamori, S.; Gurbatov, S.O.; Bhardwaj, A.K.; Kulinich, S.A. PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles. Nanomanufacturing 2023, 3, 401-415. Mussin, A.; AlJulaih, A.A.; Mintcheva, N.; Aman, D.; Iwamori, S.; Gurbatov, S.O.; Bhardwaj, A.K.; Kulinich, S.A. PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles. Nanomanufacturing 2023, 3, 401-415.

Abstract

: This article reports on polymer (PLLA, poly(L-lactic acid)) nanosheets incorporated with Fe-ion nanoparticles, aiming at using the latter nanoparticles as source to release Fe ions to facilitate burn wound healing when such nanosheets are applied on skin as biomedical tissue. Laser ablation in liquid phase was used to produce Fe-containing nanoparticles that after incorporation into PLLA nanosheets would release Fe ions when in immersed in water. Such nanoparticles prepared in chloroform are shown by XPS to be based on iron chloride and oxide phases. After incorporation into PLLA nanosheets, the ion –release test demonstrated that Fe ions could be released successfully into water at pH 7.4, which implies that such polymer nanosheets show promise for biomedical applications as potential patches for healing burn wounds. Incorporation with two different metal ions (Fe and Zn) is shown to be efficient and both types of ions were demonstrated to be released simultaneously and with comparable release rates.

Keywords

PLLA nanosheets; laser ablation in liquid; Fe-containing nanoparticles; metal-ion release; burn wound healing

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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