Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases

Nitu L Wankhede
,
Mayur B Kale
ORCID logo ,
Ashwini K Bawankule
,
Manish M Aglawe
,
Brijesh G Taksande
,
Rashmi V Trivedi
,
Milind J Umekar
,
Ankush Jamadagni
,
Prathamesh Walse
,
Sushruta Koppula
ORCID logo ,
Spandana Rajendra Kopalli
*
Version 1 : Received: 4 August 2023 / Approved: 4 August 2023 / Online: 7 August 2023 (02:28:52 CEST)

A peer-reviewed article of this Preprint also exists.

Wankhede, N.L.; Kale, M.B.; Bawankule, A.K.; Aglawe, M.M.; Taksande, B.G.; Trivedi, R.V.; Umekar, M.J.; Jamadagni, A.; Walse, P.; Koppula, S.; Kopalli, S.R. Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases. Nutrients 2023, 15, 3751. Wankhede, N.L.; Kale, M.B.; Bawankule, A.K.; Aglawe, M.M.; Taksande, B.G.; Trivedi, R.V.; Umekar, M.J.; Jamadagni, A.; Walse, P.; Koppula, S.; Kopalli, S.R. Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases. Nutrients 2023, 15, 3751.

Abstract

Avenanthramides (Avns) and its derivatives, a group of polyphenolic compounds found abundantly in Oats (Avena sativa Linn.) have emerged as a promising candidate for neuroprotection due to their immense anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Neurodegenerative diseases (NDDs), characterized by progressive degeneration of neurons, present a significant global health burden with limited therapeutic options. The phosphoinositide 3-kinase (PI3K) signalling pathway plays a crucial role in cell survival, growth, and metabolism, making it an attractive target for therapeutic intervention. Dysregulation of PI3K signalling has been implicated in the pathogenesis of various NDDs including Alzheimer's and Parkinson's disease. Avns has been shown to modulate PI3K/AKT signalling, leading to increased neuronal survival, reduced oxidative stress, and improved cognitive function. This review explores the potential of Avns polyphenols, as modulators of the PI3K signalling pathway focusing on their beneficial effects against NDDs. Further, we outlined the need for clinical exploration to elucidate the specific mechanisms of Avns action on the PI3K/AKT pathway and its potential interactions with other signalling cascades involved in neurodegeneration. Based on the available literature using relevant keywords from Google Scholar, PubMed, Scopus, Science Direct, and Web of Science, our review emphasizes the potential of Avns as a therapeutic strategy for NDDs and warrants further investigation and clinical exploration.

Keywords

Avenanthramide; AKT-Protein kinase B; Alzheimer's disease; Parkinson's disease; oxidative stress; neuroprotection

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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