Chen, Y.; Li, H.; Yi, T.-C.; Shen, J.; Zhang, J. Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions. Int. J. Mol. Sci.2023, 24, 14028.
Chen, Y.; Li, H.; Yi, T.-C.; Shen, J.; Zhang, J. Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions. Int. J. Mol. Sci. 2023, 24, 14028.
Chen, Y.; Li, H.; Yi, T.-C.; Shen, J.; Zhang, J. Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions. Int. J. Mol. Sci.2023, 24, 14028.
Chen, Y.; Li, H.; Yi, T.-C.; Shen, J.; Zhang, J. Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions. Int. J. Mol. Sci. 2023, 24, 14028.
Abstract
Notch signaling is a highly conserved pathway which occurs between adjacent cells to distinguish them. The Notch signaling cascade operates in a simple mechanism, yet Notch plays remarkably diverse roles in development to regulate cell fate determination, organ growth and tissue patterning. Originally isolated and characterized in the model insect Drosophila melanogaster, recent studies in various insect species have revealed that Notch signaling is broadly involved in the construction of insect tissues. This review focuses on providing a molecular mechanistic and developmental picture regarding the roles of Notch pathway in insects. The functions of Notch in the formation and patterning of insect embryo, wing, leg, ovary and several specific structures as well as in stress responses are summarized. These results are discussed in developmental context with an eye toward understanding the functionality of Notch signaling pathway in different insect species.
Keywords
Notch; insect; development; Drosophila
Subject
Biology and Life Sciences, Insect Science
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
