Version 1
: Received: 1 August 2023 / Approved: 2 August 2023 / Online: 3 August 2023 (02:46:08 CEST)
How to cite:
Aldaais, E.A. Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review. Preprints2023, 2023080228. https://doi.org/10.20944/preprints202308.0228.v1
Aldaais, E.A. Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review. Preprints 2023, 2023080228. https://doi.org/10.20944/preprints202308.0228.v1
Aldaais, E.A. Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review. Preprints2023, 2023080228. https://doi.org/10.20944/preprints202308.0228.v1
APA Style
Aldaais, E.A. (2023). Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review. Preprints. https://doi.org/10.20944/preprints202308.0228.v1
Chicago/Turabian Style
Aldaais, E.A. 2023 "Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review" Preprints. https://doi.org/10.20944/preprints202308.0228.v1
Abstract
Due to their distinct physical, chemical, and biological characteristics, biopolymers, in particular Poly Ethylene Glycol (PEG) and Cellulose, are frequently used in biomedical medicine as drug or vaccine delivery systems. In this study, we have done a systematic review and a meta-analysis to compare current developments in many PEG and cellulose-based hydrogels, including double network hydrogels, injectable hydrogels, sliding hydrogels, conductive hydrogels, responsive hydrogels, and nanocomposite hydrogels. The pharmacokinetic properties, including physicochemical properties, biocompatibility, biodegradability, temperature, and pH, have been studied as these critical factors are to be considered for deciding the suitability of the drug for delivery. Moreover, the study has evaluated the controlled-release parameters such as half-life, circulation time, maximum release percentage of loaded drug released, burst release, maximum release, and drug-release kinetics. Finally, the efficacy and immune response of hydrogel was studied for future choice, including the cellulose hydrogel system in COVID-related long-term vaccine delivery. The finding revealed that cellulose-based hydrogel is effective for vaccine delivery.
Keywords
Polyethylene glycol; Cellulose; Drug delivery; Vaccine delivery; Hydrogel; Immunogenicity.
Subject
Engineering, Bioengineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
