Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

DEVELOPING A PATIENT-CENTERED COMMUNITY-BASED MODEL FOR MANAGEMENT OF DRUG RESISTANT TUBERCULOSIS IN RURAL EASTERN CAPE: A COLLABORATIVE APPROACH OF HEALTH CARE FACILITIES, DIAGNOSTIC LABORATORIES AND RESEARCH INSTITUTIONS

Version 1 : Received: 1 August 2023 / Approved: 2 August 2023 / Online: 3 August 2023 (08:17:13 CEST)

How to cite: FAYE, L.M.; Bokop, C.; Vasaikar, S.; Apalata, T.; Dlatu, N. DEVELOPING A PATIENT-CENTERED COMMUNITY-BASED MODEL FOR MANAGEMENT OF DRUG RESISTANT TUBERCULOSIS IN RURAL EASTERN CAPE: A COLLABORATIVE APPROACH OF HEALTH CARE FACILITIES, DIAGNOSTIC LABORATORIES AND RESEARCH INSTITUTIONS. Preprints 2023, 2023080224. https://doi.org/10.20944/preprints202308.0224.v1 FAYE, L.M.; Bokop, C.; Vasaikar, S.; Apalata, T.; Dlatu, N. DEVELOPING A PATIENT-CENTERED COMMUNITY-BASED MODEL FOR MANAGEMENT OF DRUG RESISTANT TUBERCULOSIS IN RURAL EASTERN CAPE: A COLLABORATIVE APPROACH OF HEALTH CARE FACILITIES, DIAGNOSTIC LABORATORIES AND RESEARCH INSTITUTIONS. Preprints 2023, 2023080224. https://doi.org/10.20944/preprints202308.0224.v1

Abstract

Infectious illnesses have always posed a threat to human health, with tuberculosis (TB) being a major concern. The use of various medications and antibiotics in the fight against such illnesses has led to the emergence of drug-resistant infectious diseases, which have become increasingly dif-ficult to manage as medical and scientific research has advanced. Inadequate medical infrastruc-ture, incorrect treatment practices that exacerbate resistance patterns, and transmission within communities and healthcare facilities are the main factors contributing to the spread of drug-resistant TB. Though treating individuals with multiple drug resistance (MDR) and extreme drug resistance (XDR) strains is challenging, early identification of resistance and the imple-mentation of a well-designed treatment regimen can result in a cure. Community-based inter-ventions that address socioeconomic barriers to adherence can also enhance treatment outcomes. While there have been few studies and proposed conceptual models on how to manage and prevent various drug-resistant TB mutations and lineages, a model aimed at limiting and controlling such mutations has been developed. This paradigm seeks to bridge the gap by facilitating the exchange of knowledge among healthcare professionals (HCP) in healthcare facilities (HCF), diagnostic laboratories (DL), and research institutes (RI), particularly for underprivileged communities in the Eastern Cape. The model guide will also monitor and evaluate TB management plans

Keywords

Keywords: Model; Drug resistance TB, Collaboration and Integration

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

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