Version 1
: Received: 31 July 2023 / Approved: 1 August 2023 / Online: 2 August 2023 (10:36:20 CEST)
How to cite:
Yaffe, J.A.; Matlov Kormas, R.; Malyugin, B.E.; Boyko, M.; Tuuminen, R.; Knyazer, B. Ethnicity, Progressive Keratoconus, and Outcomes After Corneal Cross-Linking in South Israel. Preprints2023, 2023080125. https://doi.org/10.20944/preprints202308.0125.v1
Yaffe, J.A.; Matlov Kormas, R.; Malyugin, B.E.; Boyko, M.; Tuuminen, R.; Knyazer, B. Ethnicity, Progressive Keratoconus, and Outcomes After Corneal Cross-Linking in South Israel. Preprints 2023, 2023080125. https://doi.org/10.20944/preprints202308.0125.v1
Yaffe, J.A.; Matlov Kormas, R.; Malyugin, B.E.; Boyko, M.; Tuuminen, R.; Knyazer, B. Ethnicity, Progressive Keratoconus, and Outcomes After Corneal Cross-Linking in South Israel. Preprints2023, 2023080125. https://doi.org/10.20944/preprints202308.0125.v1
APA Style
Yaffe, J.A., Matlov Kormas, R., Malyugin, B.E., Boyko, M., Tuuminen, R., & Knyazer, B. (2023). Ethnicity, Progressive Keratoconus, and Outcomes After Corneal Cross-Linking in South Israel. Preprints. https://doi.org/10.20944/preprints202308.0125.v1
Chicago/Turabian Style
Yaffe, J.A., Raimo Tuuminen and Boris Knyazer. 2023 "Ethnicity, Progressive Keratoconus, and Outcomes After Corneal Cross-Linking in South Israel" Preprints. https://doi.org/10.20944/preprints202308.0125.v1
Abstract
Purpose: To assess clinical outcomes of corneal cross-linking (CXL) intervention in a population diagnosed with progressive keratoconus.
Methods: This single-center retrospective cohort study included consecutive patients who underwent standard CXL or accelerated CXL for progressive keratoconus at a major teaching hospital in south Israel between January 2015 and December 2019. Patient medical files were reviewed to extract demographic, clinical, and tomographic data from outpatient clinic reports before treatment and one year post-operatively.
Results: This study included 166 patients (representing 198 eyes), out of which 98 patients (123 eyes) were ethnically Bedouin, and 68 patients (75 eyes) were ethnically Jewish. Overall, 126 patients (144 eyes) had a follow-up of at least 12 months (16.84±5.76). The mean patient age was 20.62 ± 7.1 years old. There were significant baseline differences between the two ethnical groups in best-corrected visual acuity (BCVA; p < 0.001), uncorrected visual acuity (UCVA; p < 0.001), mean keratometry (p = 0.028), and corneal thickness (p < 0.001). Significant changes in BCVA, UCVA, and pachymetry parameters within each group were found after 12 months. Negative binomial regression analysis showed a maximal keratometry below 55D (RR=1.247, p < 0.001) and a standard CXL procedure (RR=1.147, p = 0.041) are significantly related to the stability of KC after 12 months. However, the effect size of the origin of patients is negligible (RR=1.047, p = 0.47).
Conclusions: In this study, the Bedouin population suffered from more progressive keratoconus when compared to the Jewish population. CXL was significantly effective in improving BCVA and UCVA in both groups after 12 months of follow-up.
Keywords
epidemiology; ectasia; Bedouin; Jewish; Kmax
Subject
Medicine and Pharmacology, Ophthalmology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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