Version 1
: Received: 30 July 2023 / Approved: 31 July 2023 / Online: 1 August 2023 (03:46:33 CEST)
How to cite:
Alamri, E.S.; El Rabey, H.A. The Antioxidant and Antidiabetic Activity of Vanillic Acid and Vanillic Acid-Coated Silver Nanoparticles in Streptozotocin-Induced Diabetic Male Rats. Preprints2023, 2023072144. https://doi.org/10.20944/preprints202307.2144.v1
Alamri, E.S.; El Rabey, H.A. The Antioxidant and Antidiabetic Activity of Vanillic Acid and Vanillic Acid-Coated Silver Nanoparticles in Streptozotocin-Induced Diabetic Male Rats. Preprints 2023, 2023072144. https://doi.org/10.20944/preprints202307.2144.v1
Alamri, E.S.; El Rabey, H.A. The Antioxidant and Antidiabetic Activity of Vanillic Acid and Vanillic Acid-Coated Silver Nanoparticles in Streptozotocin-Induced Diabetic Male Rats. Preprints2023, 2023072144. https://doi.org/10.20944/preprints202307.2144.v1
APA Style
Alamri, E.S., & El Rabey, H.A. (2023). The Antioxidant and Antidiabetic Activity of Vanillic Acid and Vanillic Acid-Coated Silver Nanoparticles in Streptozotocin-Induced Diabetic Male Rats. Preprints. https://doi.org/10.20944/preprints202307.2144.v1
Chicago/Turabian Style
Alamri, E.S. and Haddad A. El Rabey. 2023 "The Antioxidant and Antidiabetic Activity of Vanillic Acid and Vanillic Acid-Coated Silver Nanoparticles in Streptozotocin-Induced Diabetic Male Rats" Preprints. https://doi.org/10.20944/preprints202307.2144.v1
Abstract
The production of nanoparticles enhances the bioactivity of biological molecules for drug delivery to infection sites. This study explains how silver nanoparticles (AgNPs) coating enhanced the hypoglycemic effects of vanillic acid in male diabetic rats with diabetes brought on by streptozotocin. (STZ). Four groups of 24 rats were created for the investigation and divided into them. The first group rats (G1; untreated) were given a basal diet, whereas the other three groups all developed diabetes through STZ injection. Diabetic rats who were not getting therapy were included in the second group (G2; STZ-positive), whereas the other diabetic rats were divided into the third group (G3, vanillic acid-treated) and the fourth group (G4; AgNPs-coated vanillic acid treated). The treatment lasted four weeks. In G2, the induction of diabetes led to an increase in serum glucose, glycated proteins, renal indices, interleukin-6 (IL-6), K+, immunoglobulins, and lipid peroxidation, while decreased Ca++, Na+, and other antioxidants in the kidney tissue homogenate. In addition, aberrant signs were present in the pancreas and kidneys of diabetic rats. The renal and pancreatic tissues were effectively enhanced by vanillic acid or vanillic acid-coated AgNPs, bringing them very close to their pre-diabetic conditions. AgNPs-coated vanillic acid offered a stronger defense against STZ-induced diabetes and lessened the effects of hyperglycemia compared to ordinary vanillic acid. Additionally, using vanillic acid coated with silver nanoparticles greatly reduced inflammation when compared to using vanillic acid alone. This outcome suggests increased antioxidant activity.
Keywords
Streptozotocin; vanillic acid; silver nanoparticles; and antidiabetic drugs
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
