Crater, J.M.; Dunn, D.C.; Nixon, D.F.; Furler O’Brien, R.L. A History and Atlas of the Human CD4+ T Helper Cell. Biomedicines2023, 11, 2608.
Crater, J.M.; Dunn, D.C.; Nixon, D.F.; Furler O’Brien, R.L. A History and Atlas of the Human CD4+ T Helper Cell. Biomedicines 2023, 11, 2608.
Crater, J.M.; Dunn, D.C.; Nixon, D.F.; Furler O’Brien, R.L. A History and Atlas of the Human CD4+ T Helper Cell. Biomedicines2023, 11, 2608.
Crater, J.M.; Dunn, D.C.; Nixon, D.F.; Furler O’Brien, R.L. A History and Atlas of the Human CD4+ T Helper Cell. Biomedicines 2023, 11, 2608.
Abstract
CD4+ T cells orchestrate and regulate immunity within jawed vertebrates, yet our understanding of their evolution, development, and cellular physiology has only begun to be unearthed in the past few decades. Discoveries of genetic diseases that ablate this cellular population have provided insight into their critical functions while transcriptomics, proteomics, and highresolution microscopy have recently revealed new insights into CD4+ T cell anatomy and physiology. This article compiles historical, microscopic, and multi omics data which can be used as a reference atlas to dissect cellular physiology within these influential cells and further understand pathologies like HIV infection that inflict human CD4+ T cells.
Keywords
CD4+ T cell; Primary Immunodeficiencies; Cell Migration; Adaptive Immunity
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
