Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Complexation of Terpenes for the Production of New Antimicrobial and Antibiofilm Molecules and Their Encapsulation in Order to Improve Their Activities

Yousra EL Fannassi
,
Adem Gharsallaoui
ORCID logo ,
Simon Khelissa
,
Mohamed Amin El Amrani
ORCID logo ,
Isabelle Suisse
,
Mathieu Sauthier
,
Charafeddine Jama
,
Saïd Boudra
,
Nour-Eddine Chihib
* ORCID logo
Version 1 : Received: 25 July 2023 / Approved: 25 July 2023 / Online: 28 July 2023 (10:49:06 CEST)

A peer-reviewed article of this Preprint also exists.

El Fannassi, Y.; Gharsallaoui, A.; Khelissa, S.; El Amrani, M.A.; Suisse, I.; Sauthier, M.; Jama, C.; Boudra, S.; Chihib, N.-E. Complexation of Terpenes for the Production of New Antimicrobial and Antibiofilm Molecules and Their Encapsulation in Order to Improve Their Activities. Appl. Sci. 2023, 13, 9854. El Fannassi, Y.; Gharsallaoui, A.; Khelissa, S.; El Amrani, M.A.; Suisse, I.; Sauthier, M.; Jama, C.; Boudra, S.; Chihib, N.-E. Complexation of Terpenes for the Production of New Antimicrobial and Antibiofilm Molecules and Their Encapsulation in Order to Improve Their Activities. Appl. Sci. 2023, 13, 9854.

Abstract

Microbiological risk associated to abiotic surfaces is one of the most important issue worldwide. Surface contaminations by pathogenic bacterial biofilms or adherent cell affect a number of sectors including medical services, food industries, human services, and the environment. There is a need to synthesize or to setup novel antimicrobials. Terpenes are usually found in essential oils and have potent antimicrobial activities. However, the direct use of these molecules is often inefficient due to their low water solubility, loss of volatile compounds, thermal degradation, oxidation and toxicity. The need for biosourced compounds with antimicrobial activity, low toxicity and low cost promote the search for new stable metal complexes based on terpene ligands. This will enable the manufacture of value-added products with a lower environmental impact, as well as the production of high value added commodities. The goal of this review is to discuss the development of novel antimicrobial complexes derived from terpenes. In addition, this review explored how to improve their bioactivities and characteristics by using a formulation based on microencapsulation.

Keywords

terpenes; metallic ions; complexes; microencapsulation; biofilm

Subject

Biology and Life Sciences, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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