Cadar, R.; Lupascu Ursulescu, C.; Vasilescu, A.M.; Trofin, A.M.; Zabara, M.; Rusu-Andriesi, D.; Ciuntu, B.; Muzica, C.; Lupascu, C.D. Challenges and Solutions in the Management of Hepatocellular Carcinoma Associated with Non-Alcoholic Fatty Liver Disease. Life2023, 13, 1987.
Cadar, R.; Lupascu Ursulescu, C.; Vasilescu, A.M.; Trofin, A.M.; Zabara, M.; Rusu-Andriesi, D.; Ciuntu, B.; Muzica, C.; Lupascu, C.D. Challenges and Solutions in the Management of Hepatocellular Carcinoma Associated with Non-Alcoholic Fatty Liver Disease. Life 2023, 13, 1987.
Cadar, R.; Lupascu Ursulescu, C.; Vasilescu, A.M.; Trofin, A.M.; Zabara, M.; Rusu-Andriesi, D.; Ciuntu, B.; Muzica, C.; Lupascu, C.D. Challenges and Solutions in the Management of Hepatocellular Carcinoma Associated with Non-Alcoholic Fatty Liver Disease. Life2023, 13, 1987.
Cadar, R.; Lupascu Ursulescu, C.; Vasilescu, A.M.; Trofin, A.M.; Zabara, M.; Rusu-Andriesi, D.; Ciuntu, B.; Muzica, C.; Lupascu, C.D. Challenges and Solutions in the Management of Hepatocellular Carcinoma Associated with Non-Alcoholic Fatty Liver Disease. Life 2023, 13, 1987.
Abstract
Non-alcoholic fatty liver disease (NAFLD) has gained attention in the last few years due to its increasing prevalence worldwide becoming a global epidemic. This review aims to discuss the latest recommendations regarding diagnosis and treatment of NAFLD-associated HCC and the remaining challenges. Thus, there is a high amount of data derived from basic and clinical studies that revealed the molecular pathways which drive NAFLD-associated hepatocellular carcinoma (HCC). Based on these findings, new prevention, surveillance and treatment strategies are emerging. However, current data on treatment modalities in NAFLD-associated HCC are still scarce, but based on subgroup analysis results from non-NAFLD HCC studies are promising and could provide a basis for future research agenda to address NAFLD/NASH patients. Conclusion: Due to the pandemic proportions that NAFLD gained in the last few years, there is a high amount of data derived from basic and clinical studies that revealed the molecular path-ways which drive NAFLD-associated HCC. Based on these findings, new prevention, surveillance and treatment strategies could be developed at an individual level.
Keywords
non-alcoholic fatty liver disease; hepatocellular carcinoma; management; challenges and solutions
Subject
Medicine and Pharmacology, Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
