Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma

Carl Mathis Wild
,
Fabian Garrido
,
Christian Dannecker
ORCID logo ,
Melitta B Köpke
ORCID logo ,
Marie-Christine Chateau
,
Florence Boissière-Michot
ORCID logo ,
Helene H Heidegger
,
Aurelia Vattai
,
Mirjana Kessler
,
Udo Jeschke
* ORCID logo ,
Vincent Cavaillès
ORCID logo
Version 1 : Received: 24 July 2023 / Approved: 25 July 2023 / Online: 25 July 2023 (13:10:32 CEST)

A peer-reviewed article of this Preprint also exists.

Wild, C.M.; Garrido, F.; Dannecker, C.; Köpke, M.B.; Chateau, M.-C.; Boissière-Michot, F.; Heidegger, H.H.; Vattai, A.; Kessler, M.; Jeschke, U.; Cavaillès, V. Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma. Cancers 2023, 15, 4952. Wild, C.M.; Garrido, F.; Dannecker, C.; Köpke, M.B.; Chateau, M.-C.; Boissière-Michot, F.; Heidegger, H.H.; Vattai, A.; Kessler, M.; Jeschke, U.; Cavaillès, V. Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma. Cancers 2023, 15, 4952.

Abstract

There exists a variety of studies about tumor-infiltrating lymphocytes (TILs) in cervical cancer, but their prognostic value in correlation to the histopathological subtype was never investigated. Therefore, the aim of this study was to quantify TILs in a panel of 250 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIL levels were significantly increased in the subgroup of squamous cell carcinomas in comparison to adenocarcinomas. In squamous cell carcinomas, TIL infiltration shows a negative correlation to age, FIGO stage and to the histone protein modification H3K4me3. Moreover, in adenocarcinomas, it was positively correlated to p16 and to the glucocorticoid receptor and inversely correlated to the MDM2 protein and to H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease free survival (DFS) in patients with squamous cell carcinomas, those bearing tumors with the strongest TIL infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIL levels and prognosis in patients with cervix squamous cell carcinomas vs patients with cervix adenocarcinomas.

Keywords

cervical cancer; tumor-infiltrating lymphocytes (TILs); adenocarcinoma; squamous cell carcinoma; disease free survival (DFS)

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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