Version 1
: Received: 21 July 2023 / Approved: 21 July 2023 / Online: 24 July 2023 (10:37:38 CEST)
How to cite:
Wiktor, Ł.; Osadnik, B.; Damps, M. Can Local Infiltration Analgesia Supplement Tranexamic Acid in Reducing Blood Loss for Total Knee Arthroplasty?. Preprints2023, 2023071558. https://doi.org/10.20944/preprints202307.1558.v1
Wiktor, Ł.; Osadnik, B.; Damps, M. Can Local Infiltration Analgesia Supplement Tranexamic Acid in Reducing Blood Loss for Total Knee Arthroplasty?. Preprints 2023, 2023071558. https://doi.org/10.20944/preprints202307.1558.v1
Wiktor, Ł.; Osadnik, B.; Damps, M. Can Local Infiltration Analgesia Supplement Tranexamic Acid in Reducing Blood Loss for Total Knee Arthroplasty?. Preprints2023, 2023071558. https://doi.org/10.20944/preprints202307.1558.v1
APA Style
Wiktor, Ł., Osadnik, B., & Damps, M. (2023). Can Local Infiltration Analgesia Supplement Tranexamic Acid in Reducing Blood Loss for Total Knee Arthroplasty?. Preprints. https://doi.org/10.20944/preprints202307.1558.v1
Chicago/Turabian Style
Wiktor, Ł., Bartłomiej Osadnik and Maria Damps. 2023 "Can Local Infiltration Analgesia Supplement Tranexamic Acid in Reducing Blood Loss for Total Knee Arthroplasty?" Preprints. https://doi.org/10.20944/preprints202307.1558.v1
Abstract
Purpose: The study aimed to investigate the efficacy of TXA supplemented with local infiltration analgesia (LIA) in reducing blood loss in patients undergoing total knee replacement.
Materials: A retrospective study on 530 individuals with a mean age of 71,44 years after posterior stabilized total knee arthroplasty was evaluated. Patients were divided into three groups, corresponding to the method of bleeding control: I - patients without additional bleeding protocol (control group); II - patients with iV TXA administration (TXA group); III - patients with exact TXA protocol combined with intraoperative local infiltration analgesia (TXA + LIA group). Blood loss was measured as a substitute for blood loss by maximal Hb drop compared to preoperative Hb level.
Results: The mean hospitalization for patients from the control group was 7.02 (SD 1.34) days, 6.08 (SD 1.06) days for the TXA group, and 5.56 (SD 0.79) for the TXA + LIA group. The most significant hemoglobin drop was found in the control group, which amounted to an average of 30.08% output value. In the TXA group, the decrease in hemoglobin was, on average, 25.17% (p<0.001), and in the TXA + LIA group, it was 23.67% (p<0.001). A decrease in the rate of allogeneic blood transfusions was observed, which was 24.4% in the control group, 9.9% in the TXA group, and 8% in TXA + LIA group (p<0.01).
Conclusions: Compared to the separate administration of tranexamic acid, the combination of perioperative administration with local infiltration analgesia statistically significantly reduces blood loss in patients after total knee replacement.
Keywords
knee; arthroplasty; tranexamic acid; local infiltration analgesia; blood loss
Subject
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
