Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preclinical Studies of Antimicrobial and Wound-Healing Effects of the High-Intensity Optical Irradiation Apparatus "Zarnitsa-A"

Valery Vladimirovich Bagrov
,
Igor Valentinovich Bukhtiyarov
,
Lev Yuryevich Volodin
,
Evgeny Vladimirovich Zibarev
,
Alexander Semenovich Kamrukov
* ORCID logo ,
Andrey Valeryevich Kondratiev
,
Vladimir Ivanovich Krylov
,
Sofya Maksimovna Nikonova
,
Dmitry Olegovich Novikov
,
Kirill Andreevich Semenov
Version 1 : Received: 18 July 2023 / Approved: 18 July 2023 / Online: 19 July 2023 (09:34:21 CEST)

A peer-reviewed article of this Preprint also exists.

Bagrov, V.V.; Bukhtiyarov, I.V.; Volodin, L.Y.; Zibarev, E.V.; Kamrukov, A.S.; Kondratiev, A.V.; Krylov, V.I.; Nikonova, S.M.; Novikov, D.O.; Semenov, K.A. Preclinical Studies of the Antimicrobial and Wound-Healing Effects of the High-Intensity Optical Irradiation “Zarnitsa-A” Apparatus. Appl. Sci. 2023, 13, 10794. Bagrov, V.V.; Bukhtiyarov, I.V.; Volodin, L.Y.; Zibarev, E.V.; Kamrukov, A.S.; Kondratiev, A.V.; Krylov, V.I.; Nikonova, S.M.; Novikov, D.O.; Semenov, K.A. Preclinical Studies of the Antimicrobial and Wound-Healing Effects of the High-Intensity Optical Irradiation “Zarnitsa-A” Apparatus. Appl. Sci. 2023, 13, 10794.

Abstract

A new approach to the treatment of wound lesions, which are complicated by the presence of polyresistant microflora and a possible immunodeficiency background has been proposed. It involves treating the wound surface with high-intensity pulsed optical radiation of a continuous spectrum, continuously covering the entire UV range (from 200 to 400 nm), visible and near infrared region of the spectrum. A pulsed xenon lamp is used as a radiation source. A description of the design and technical characteristics of the developed device for high-intensity optical irradiation "Zarnitsa-A", which implements the proposed medical technology for wound therapy, is represented. The results of preclinical studies of the apparatus in vitro and in vivo are represented hereinafter. The article shows that the apparatus exposure has pronounced bactericidal and wound-healing properties. The apparatus action reliably provides higher rates of wound healing compared to the use of only a typical antibacterial and wound healing agent – “Levomekol” ointment.

Keywords

high-intensity broadband optical radiation; pathogens with multiple drug resistance; pulsed xenon lamp; phototherapy devise; wound healing; dose

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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