Loghin, I.I.; Cobaschi, M.; Rusu, Ş.A.; Silvaş, G.; Dorobăţ, C.M. Tuberculous Meningitis in HIV-Positive Patients in North-Eastern Romania. Preprints2023, 2023071138. https://doi.org/10.20944/preprints202307.1138.v1
APA Style
Loghin, I.I., Cobaschi, M., Rusu, Ş.A., Silvaş, G., & Dorobăţ, C.M. (2023). Tuberculous Meningitis in HIV-Positive Patients in North-Eastern Romania. Preprints. https://doi.org/10.20944/preprints202307.1138.v1
Chicago/Turabian Style
Loghin, I.I., George Silvaş and Carmen Mihaela Dorobăţ. 2023 "Tuberculous Meningitis in HIV-Positive Patients in North-Eastern Romania" Preprints. https://doi.org/10.20944/preprints202307.1138.v1
Abstract
: Background and objectives: One of the most severe symptoms of extrapulmonary tuberculosis (TBEP) is tuberculous meningitis (TBM) which is linked to significant morbidity and high mortality. It is well recognized that HIV-positive people are more likely to develop TBEP, including TBM, especially if they have severe immunodeficiencies. Material and methods: We conducted a retrospective clinical study based on hospital medical records of the diagnosed patients with HIV/AIDS and Tuberculous Meningitis in North-eastern Romania, hospitalized at "Sf. Parascheva" Clinical Hospital of Infectious Diseases from Iasi. We aim to highlight the profile and the caracteristics of the HIV/AIDS and Tuberculous Meningitis coinfection cases. The time frame under study was from January 1st, 2010, to December 1st, 2022. Results: Our Center has a total number of patients on record of 1692. Patients co-infected with HIV- TB were 195 of which 19 cases were HIV- TBM coinfection and it was more common in women. From this total, 6 cases were late presenters and 13 patients were already in the center's records with a deficient immunological viral status, non-compliant, and non-adherent to antiretroviral therapy. The average age in the study group was 27 years old. The mean admission day number was 17.73 days. CSF findings (qualitative and quantitaitve examination, biochemestry) were in accordance with the literature. Conclusions: The key to the management of the HIV-positive patient is the multidisciplinary approach and access to antiretroviral therapy. We must find and eliminate obstacles affecting patients and the healthcare system. In order to increase ART uptake among HIV-infected TB patients and to put an end to the TB and HIV epidemics.
Keywords
HIV infection; Tuberculous meningitis; TB-DOTS; Mycobacterium tuberculosis
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
