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Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”?
Version 1
: Received: 28 June 2023 / Approved: 29 June 2023 / Online: 29 June 2023 (12:32:09 CEST)
A peer-reviewed article of this Preprint also exists.
Reyes-Aldasoro, C.C. Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”? Cancers 2023, 15, 3796. Reyes-Aldasoro, C.C. Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”? Cancers 2023, 15, 3796.
Abstract
The Oxford English Dictionary includes 17 definitions for the word “model” as a noun and other 11 as a verb. Therefore, context is necessary to understand the meaning of the word model. For in-stance, “model railways” refer to replicas of railways and trains at a smaller scale and a “model student” refers to an exemplar individual. In some cases, a specific context, like cancer research, may not be sufficient to provide one specific meaning of a model. Even if the context is narrowed, specifically to the research related to the tumour microenvironment, a “model” can be understood in a wide variety of ways, from an animal model, to a mathematical expression. This paper presents a review of the different “models” of the tumour microenvironment grouped by the different def-initions of the word into four categories: model organisms, in vitro models, mathematical models, and computational models. Then, the frequency of different meanings of the word “model” related to the tumour microenvironment is measured from the number of entries in the MEDLINE database of the United States National Library of Medicine at the National Institutes of Health. The frequency of the main components of the microenvironment and the organ-related cancers modelled are also assessed quantitatively with specific keywords. Whilst animal models, in particular xenografts and mouse models are the most common used “models”, the number of entries have been slowly de-creasing. Mathematical models, prognostic and risk models follow in frequency and these have been growing in use.
Keywords
Tumour microenvironment; In vivo model; In vitro model; Mathematical model; Computational model
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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