Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Fertility Outcome of Addition of Assisted Oocyte Activation Into Spindle View-Assisted Intracytoplasmic Sperm Injection in Patients With Low Fertilization Rate

Version 1 : Received: 28 June 2023 / Approved: 28 June 2023 / Online: 28 June 2023 (05:22:26 CEST)

How to cite: Lo, W.; Lin, C.; Li, C.; Hou, C.; Dai, L.; Wu, H. The Fertility Outcome of Addition of Assisted Oocyte Activation Into Spindle View-Assisted Intracytoplasmic Sperm Injection in Patients With Low Fertilization Rate. Preprints 2023, 2023061952. https://doi.org/10.20944/preprints202306.1952.v1 Lo, W.; Lin, C.; Li, C.; Hou, C.; Dai, L.; Wu, H. The Fertility Outcome of Addition of Assisted Oocyte Activation Into Spindle View-Assisted Intracytoplasmic Sperm Injection in Patients With Low Fertilization Rate. Preprints 2023, 2023061952. https://doi.org/10.20944/preprints202306.1952.v1

Abstract

Is there any possible synergic effect of fertility outcome between spindle view-assisted intracyto-plasmic sperm injection (SV-ICSI) with or without assisted oocyte activation (AOA) for patients with low fertilization rate history? To explore the answer, a retrospective study was held in our fertility center by reviewing patients receiving SV-ICSI during 2019/03 to 2023/06. Total 47 pa-tients were included, the fertility outcomes of intervention group (AOA-SV-ICSI, 14 patients) and control group (SV-ICSI, 33 patients), such as fertilization rate, blastocyst formation rate and clin-ical pregnancy rate, were analyzed. The blastocyst formation rate between groups was signifi-cantly higher in AOA-SV-ICSI group (p=0.020), but the fertilization rate and clinical pregnancy rate did not reach any statistical significance. This discovery of increased blastocyst formation rate in low fertilization rate patients could possibly help them in getting more usable embryos in fertility treatment.

Keywords

Assisted oocyte activation; ICSI; polarization microscopy; fertilization failure; blastocyst

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

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