Jiang, X.; Fielding, L.A.; Davis, H.; Carroll, W.; Lisic, E.C.; Deweese, J.E. Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes. Int. J. Mol. Sci.2023, 24, 12010.
Jiang, X.; Fielding, L.A.; Davis, H.; Carroll, W.; Lisic, E.C.; Deweese, J.E. Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes. Int. J. Mol. Sci. 2023, 24, 12010.
Jiang, X.; Fielding, L.A.; Davis, H.; Carroll, W.; Lisic, E.C.; Deweese, J.E. Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes. Int. J. Mol. Sci.2023, 24, 12010.
Jiang, X.; Fielding, L.A.; Davis, H.; Carroll, W.; Lisic, E.C.; Deweese, J.E. Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes. Int. J. Mol. Sci. 2023, 24, 12010.
Abstract
Topoisomerases, common targets for anti-tumor therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism. The potential anti-cancer effect of thiosemicarbazones (TSC) and metal-TSC complexes has been demonstrated by targeting several biological processes, including DNA metabolism. Human topoisomerases were discovered among the molecular targets for TSCs, and metal-chelated TSCs specifically displayed significant inhibition. The processes by which metal-TSCs or TSCs inhibit topoisomerases are still being studied. In this brief review, we summarize the TSCs and metal-TSCs that inhibit various types of human topoisomerases.
Keywords
topoisomerase; thiosemicarbazone; cancer; DNA
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
