Rizzetto, G.; De Simoni, E.; Molinelli, E.; Offidani, A.; Simonetti, O. Efficacy of Pembrolizumab in Advanced Melanoma: A Narrative Review. Int. J. Mol. Sci.2023, 24, 12383.
Rizzetto, G.; De Simoni, E.; Molinelli, E.; Offidani, A.; Simonetti, O. Efficacy of Pembrolizumab in Advanced Melanoma: A Narrative Review. Int. J. Mol. Sci. 2023, 24, 12383.
Rizzetto, G.; De Simoni, E.; Molinelli, E.; Offidani, A.; Simonetti, O. Efficacy of Pembrolizumab in Advanced Melanoma: A Narrative Review. Int. J. Mol. Sci.2023, 24, 12383.
Rizzetto, G.; De Simoni, E.; Molinelli, E.; Offidani, A.; Simonetti, O. Efficacy of Pembrolizumab in Advanced Melanoma: A Narrative Review. Int. J. Mol. Sci. 2023, 24, 12383.
Abstract
Introduction: pembrolizumab showed to increase survival in patients with metastatic melanoma, Con-sidering the numerous oncoming studies, we decided to conduct a narrative review of the latest efficacy evidence regarding the use of pembrolizumab, alone or in combination, in patients with metastatic melanoma. (2) Methods: A search was conducted on Pubmed using "pembrolizumab," and "metastatic melanoma" as keywords, considering studies from 2022 onward. (3) results: we reviewed pembroli-zumab and associations, cost-effectiveness, virus, advanced acral melanoma, long-term outcomes, re-al-life data, biomarkers, obesity, and vaccines (4) Conclusions: pembrolizumab is a fundamental op-tion in the therapy of metastatic melanoma. However, a certain group of patients do not respond and therefore new combination options need to be evaluated. In particular, the use of vaccines tailored to tumor epitopes could represent a breakthrough in the treatment of resistant forms. Further studies with larger sample numbers are needed to confirm preliminary results.
Keywords
advanced melanoma; pembrolizumab; immunotherapy
Subject
Medicine and Pharmacology, Dermatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
