Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Validation of Lead-DBS β-oscillation Localization with Directional Electrodes

Colette Boëx
* ORCID logo ,
Abdullah Al Awadhi
,
Rémi Tyrand
,
Marco Vincenzo Corniola
,
Astrid Kibleur
,
Vanessa Fleury
ORCID logo ,
Pierre R. Burkhard
,
Shahan Momjian
Version 1 : Received: 22 June 2023 / Approved: 23 June 2023 / Online: 23 June 2023 (12:02:12 CEST)

A peer-reviewed article of this Preprint also exists.

Boëx, C.; Awadhi, A.A.; Tyrand, R.; Corniola, M.V.; Kibleur, A.; Fleury, V.; Burkhard, P.R.; Momjian, S. Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes. Bioengineering 2023, 10, 898. Boëx, C.; Awadhi, A.A.; Tyrand, R.; Corniola, M.V.; Kibleur, A.; Fleury, V.; Burkhard, P.R.; Momjian, S. Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes. Bioengineering 2023, 10, 898.

Abstract

The Lead-DBS imaging toolbox reconstructs the location of β-oscillations in the subthalamic nucleus (STN) in patients with Parkinson’s disease. The objective was to compare this probabilistic location with those of intraoperative monopolar β-oscillations (Vercise Cartesia directional electrodes, Boston Scientific). Also, the efficacy of stimulated structures in reducing motor symptoms were analysed. β-oscillations were computed from local field potentials [0.5-3kHz] by using shielded wires for monopolar recordings with an extracranial shielded reference. For each electrode contact, power spectral densities of the β-band [13-31Hz] were compared with those of all eight electrode contacts. The DISTAL, electrophysiological, and DBS target atlases of the Lead-DBS toolbox were applied to the reconstructed electrodes from preoperative MRI and postoperative CT. Thirty-six electrodes (20 patients: 7 female, 13 male; 16/20 both, 4/20 single STN) were analysed. Stimulation sites dorsal and/or lateral to the sensorimotor STN were most efficient. In 33/36 electrodes at least one contact was measured with stronger β-oscillations, 23 in or touching the ventral subpart of the probabilistic volume with β-oscillations, 10 not located in or touching but adjacent to this volume; in 3/36 electrodes, no contact was found with β-oscillations, they were distant from this volume. Monopolar local field potentials confirmed the ventral subpart of the probabilistic β-oscillations.

Keywords

Imaging toolbox; Local field potentials; Lead-DBS; subthalamic nucleus; Parkinson’s disease

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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