Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Rapidly Growing Ulcerated Breast Cancer in a 46-year-old Female Patient

Paolo Izzo
* ORCID logo ,
Luciano Izzo
,
Fabrizio Ceci
ORCID logo ,
Silvia Lai
ORCID logo ,
Andrea Polistena
ORCID logo ,
Simone Sibio
ORCID logo ,
Massimo Codacci-Pisanelli
,
Daniele Crocetti
,
Raimondo Gabriele
ORCID logo ,
Claudia De Intinis
ORCID logo ,
Sara Izzo
Version 1 : Received: 21 June 2023 / Approved: 22 June 2023 / Online: 22 June 2023 (15:00:18 CEST)

How to cite: Izzo, P.; Izzo, L.; Ceci, F.; Lai, S.; Polistena, A.; Sibio, S.; Codacci-Pisanelli, M.; Crocetti, D.; Gabriele, R.; De Intinis, C.; Izzo, S. Rapidly Growing Ulcerated Breast Cancer in a 46-year-old Female Patient. Preprints 2023, 2023061637. https://doi.org/10.20944/preprints202306.1637.v1 Izzo, P.; Izzo, L.; Ceci, F.; Lai, S.; Polistena, A.; Sibio, S.; Codacci-Pisanelli, M.; Crocetti, D.; Gabriele, R.; De Intinis, C.; Izzo, S. Rapidly Growing Ulcerated Breast Cancer in a 46-year-old Female Patient. Preprints 2023, 2023061637. https://doi.org/10.20944/preprints202306.1637.v1

Abstract

(1) Background: This case report focuses on a 46-year-old female patient diagnosed with a rare and aggressive form of breast cancer known as rapidly growing, ulcerated breast cancer. The patient exhibited rapid progression of the disease, experiencing discomfort and noticeable changes in the size and texture of the affected breast over a short period of time; (2) Methods: An intensive neoadjuvant chemotherapy regimen was employed as the primary treatment approach. The patient's response to this treatment was closely monitored and assessed. Various diagnostic tests and imaging techniques were utilized to evaluate the extent of the disease and track its response to the chemotherapy; (3) Results: The patient's response to the neoadjuvant chemotherapy regimen was remarkable, resulting in a complete pathologic response. This outcome, although unusual in rapidly growing, ulcerated breast cancers, highlights the effectiveness of neoadjuvant chemotherapy in managing large, locally advanced breast cancers; (4) Conclusions: The multidisciplinary approach employed in managing this complex breast cancer case proved to be crucial to the patient's favorable outcome. Despite the aggressive nature of the disease and the challenges posed by the rapid growth and ulceration, the patient achieved a positive result. This case contributes to the limited clinical literature on such unusual and aggressive breast cancer cases, providing valuable insights for future clinical practice.8

Keywords

rapidly growing ulcerated breast cancer; intensive neoadjuvant chemotherapy; skin ulceration; invasive ductal carcinoma; doxorubicin; cyclophosphamide.

Subject

Medicine and Pharmacology, Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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