Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effects of Vasopressin Receptor Agonists During the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies

Eleni Laou
,
Nikolaos Papagiannakis
ORCID logo ,
Androniki Papadopoulou
,
Theodora Choratta
ORCID logo ,
Minas Sakellakis
,
Mariachiara Ippolito
ORCID logo ,
Ioannis Pantazopoulos
ORCID logo ,
Andrea Cortegiani
,
Athanasios Chalkias
* ORCID logo
Version 1 : Received: 19 June 2023 / Approved: 20 June 2023 / Online: 20 June 2023 (14:57:33 CEST)

A peer-reviewed article of this Preprint also exists.

Laou, E.; Papagiannakis, N.; Papadopoulou, A.; Choratta, T.; Sakellakis, M.; Ippolito, M.; Pantazopoulos, I.; Cortegiani, A.; Chalkias, A. Effects of Vasopressin Receptor Agonists during the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Experimental and Clinical Studies. J. Pers. Med. 2023, 13, 1143. Laou, E.; Papagiannakis, N.; Papadopoulou, A.; Choratta, T.; Sakellakis, M.; Ippolito, M.; Pantazopoulos, I.; Cortegiani, A.; Chalkias, A. Effects of Vasopressin Receptor Agonists during the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Experimental and Clinical Studies. J. Pers. Med. 2023, 13, 1143.

Abstract

Background: The clinical impact of vasopressin in hemorrhagic shock remains largely unknown. Objective: This systematic review and meta-analysis was designed to investigate the effects of vasopressin receptor agonists during the resuscitation of hemorrhagic shock. Methods: A systematic search of PubMed (MEDLINE), Scopus, and PubMed Central was conducted for relevant articles. Preclinical (animal) and clinical studies were included. The primary objective was to investigate the correlation of vasopressin receptor agonist use with mortality and various hemodynamic parameters. Results: Data extraction was possible in 13 animal studies and two clinical studies. Differences in risk of mortality between patients who received a vasopressin receptor agonist were not statistically significant when compared to those who were not treated with such agents [RR (95%CI): 1.17 (0.67, 2.08); p=0.562; I2 = 50%]. The available data were insufficient to conduct a meta-analysis assessing the effect of vasopressin receptor agonists on hemodynamics. Drawing safe conclusions from animal studies was challenging, due to significant heterogeneity in terms of species and dosage of vasopressin receptor agonists across studies. Conclusions: Differences in risk of mortality between patients who received a vasopressin receptor agonist were not statistically significant when compared to those who were not treated with such agents after hemorrhagic shock.

Keywords

vasopressin; vasopressin receptor agonist; hemorrhagic shock; resuscitation; hemodynamics; outcome

Subject

Medicine and Pharmacology, Anesthesiology and Pain Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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