Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Ratio of Extracellular to Intracellular Water is Associated with Permanent Catheter Patency Survival in Patients Receiving Maintenance Hemodialysis

Moo Jun Kim
ORCID logo ,
Jae-Wan Jeon
,
Hae-Ri Kim
ORCID logo ,
Hyerim Park
,
Suyeon Han
,
Yunkyeong Hwang
,
Heewon Park
,
Kyungho Park
,
Eu-Jin Lee
,
Young-rok Ham
ORCID logo ,
Ki Ryang Na
* ,
Kang-Wook Lee
,
Dae Eun Choi
*
Version 1 : Received: 19 June 2023 / Approved: 20 June 2023 / Online: 20 June 2023 (12:20:54 CEST)

A peer-reviewed article of this Preprint also exists.

Kim, M.-J.; Jeon, J.-W.; Kim, H.-R.; Park, H.; Han, S.; Hwang, Y.; Park, H.; Park, K.; Lee, E.-J.; Ham, Y.-R.; Na, K.-R.; Lee, K.-W.; Choi, D.-E. Ratio of Extracellular to Intracellular Water Is Associated with Permanent Catheter Patency Survival in Patients Receiving Maintenance Hemodialysis. Diagnostics 2023, 13, 2545. Kim, M.-J.; Jeon, J.-W.; Kim, H.-R.; Park, H.; Han, S.; Hwang, Y.; Park, H.; Park, K.; Lee, E.-J.; Ham, Y.-R.; Na, K.-R.; Lee, K.-W.; Choi, D.-E. Ratio of Extracellular to Intracellular Water Is Associated with Permanent Catheter Patency Survival in Patients Receiving Maintenance Hemodialysis. Diagnostics 2023, 13, 2545.

Abstract

Patients undergoing dialysis through a permanent catheter often experience infection or malfunction. However, few studies have clarified the predictors of permanent catheter patency survival in patients undergoing hemodialysis. We assessed the relationship between parameters of body composition monitoring (BCM) determined before the initiation of dialysis and the patency survival of the permanent catheters inserted in 179 patients who commenced hemodialysis between January 14, 2020 and August 31, 2021. The relationships between permanent catheter patency at 6 weeks and BCM parameters, laboratory tests, age, sex, comorbidities, and medications at baseline were studied using Kaplan–Meier survival curves. Permanent catheter patency was observed to be superior at high extracellular-to-intracellular (ECW/ICW) ratio (P<0.005). After adjustment for covariates, the ECW/ICW ratio remained an independent factor associated with permanent catheter patency survival. When patients with non-patent catheters were subdivided into infection and malfunction groups, and the associations of BCM parameters were evaluated in those groups, the ECW/ICW ratio was not significantly associated with permanent catheter patency survival in the infection group (P = 0.327); instead, a significant association was found for the lean tissue index (P<0.001). In the malfunction group, the ECW/ICW ratio remained significantly associated with permanent catheter patency survival (P < 0.001).

Keywords

body composition monitoring; extracellular water; intracellular water; hemodialysis; permanent catheter; catheter patency; infection; malfunction

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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